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PMID:2177474
| Citation |
Steger, HF, Söllner, T, Kiebler, M, Dietmeier, KA, Pfaller, R, Trülzsch, KS, Tropschug, M, Neupert, W and Pfanner, N (1990) Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J. Cell Biol. 111:2353-63 |
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| Abstract |
We have identified the yeast homologue of Neurospora crassa MOM72, the mitochondrial import receptor for the ADP/ATP carrier (AAC), by functional studies and by cDNA sequencing. Mitochondria of a yeast mutant in which the gene for MOM72 was disrupted were impaired in specific binding and import of AAC. Unexpectedly, we found a residual, yet significant import of AAC into mitochondria lacking MOM72 that occurred via the receptor MOM19. We conclude that both MOM72 and MOM19 can direct AAC into mitochondria, albeit with different efficiency. Moreover, the precursor of MOM72 apparently does not require a positively charged sequence at the extreme amino terminus for targeting to mitochondria. |
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| Keywords |
Amino Acid Sequence; Base Sequence; DNA, Fungal/genetics; Fungal Proteins; Genes, Fungal; Kinetics; Membrane Proteins; Mitochondria/enzymology; Mitochondrial ADP, ATP Translocases/genetics; Mitochondrial ADP, ATP Translocases/metabolism; Mitochondrial Membrane Transport Proteins; Molecular Sequence Data; Molecular Weight; Neurospora crassa/enzymology; Neurospora crassa/genetics; Protein Processing, Post-Translational; Receptors, Cell Surface/genetics; Receptors, Cell Surface/isolation & purification; Receptors, Cell Surface/metabolism; Receptors, Cytoplasmic and Nuclear; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins; Sequence Homology, Nucleic Acid |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
YEAST:TOM70 |
involved_in |
GO:0045039: protein insertion into mitochondrial inner membrane |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
YEAST:TOM70 |
contributes_to |
GO:0008320: protein transmembrane transporter activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
YEAST:TOM70 |
involved_in |
GO:0045039: protein insertion into mitochondrial inner membrane |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
See also
References
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