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PMID:2177474

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Citation

Steger, HF, Söllner, T, Kiebler, M, Dietmeier, KA, Pfaller, R, Trülzsch, KS, Tropschug, M, Neupert, W and Pfanner, N (1990) Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J. Cell Biol. 111:2353-63

Abstract

We have identified the yeast homologue of Neurospora crassa MOM72, the mitochondrial import receptor for the ADP/ATP carrier (AAC), by functional studies and by cDNA sequencing. Mitochondria of a yeast mutant in which the gene for MOM72 was disrupted were impaired in specific binding and import of AAC. Unexpectedly, we found a residual, yet significant import of AAC into mitochondria lacking MOM72 that occurred via the receptor MOM19. We conclude that both MOM72 and MOM19 can direct AAC into mitochondria, albeit with different efficiency. Moreover, the precursor of MOM72 apparently does not require a positively charged sequence at the extreme amino terminus for targeting to mitochondria.

Links

PubMed PMC2116357

Keywords

Amino Acid Sequence; Base Sequence; DNA, Fungal/genetics; Fungal Proteins; Genes, Fungal; Kinetics; Membrane Proteins; Mitochondria/enzymology; Mitochondrial ADP, ATP Translocases/genetics; Mitochondrial ADP, ATP Translocases/metabolism; Mitochondrial Membrane Transport Proteins; Molecular Sequence Data; Molecular Weight; Neurospora crassa/enzymology; Neurospora crassa/genetics; Protein Processing, Post-Translational; Receptors, Cell Surface/genetics; Receptors, Cell Surface/isolation & purification; Receptors, Cell Surface/metabolism; Receptors, Cytoplasmic and Nuclear; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins; Sequence Homology, Nucleic Acid

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

YEAST:TOM70

involved_in

GO:0045039: protein insertion into mitochondrial inner membrane

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:TOM70

contributes_to

GO:0008320: protein transmembrane transporter activity

ECO:0000315: mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

YEAST:TOM70

involved_in

GO:0045039: protein insertion into mitochondrial inner membrane

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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