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PMID:21772250

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Citation

Vanneste, S, Coppens, F, Lee, E, Donner, TJ, Xie, Z, Van Isterdael, G, Dhondt, S, De Winter, F, De Rybel, B, Vuylsteke, M, De Veylder, L, Friml, J, Inzé, D, Grotewold, E, Scarpella, E, Sack, F, Beemster, GT and Beeckman, T (2011) Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis. EMBO J. 30:3430-41

Abstract

In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.

Links

PubMed PMC3160660 Online version:10.1038/emboj.2011.240

Keywords

Arabidopsis/cytology; Arabidopsis/genetics; Arabidopsis Proteins/biosynthesis; Arabidopsis Proteins/genetics; Arabidopsis Proteins/physiology; Cell Cycle; Cell Division; Cyclin A2/biosynthesis; Cyclin A2/genetics; Cyclin A2/physiology; Down-Regulation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Morphogenesis; Organ Specificity; Plant Leaves/metabolism; Plant Roots/metabolism; Polyploidy; Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:MYB88

involved_in

GO:0006355: regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:CCA22

acts_upstream_of_or_within

GO:0010389: regulation of G2/M transition of mitotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G15570
AGI_LocusCode:AT1G80370

P

Seeded From UniProt

complete

ARATH:CCA22

acts_upstream_of_or_within

GO:2000123: positive regulation of stomatal complex development

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G25380

P

Seeded From UniProt

complete

ARATH:CCA23

acts_upstream_of_or_within

GO:0010389: regulation of G2/M transition of mitotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G11300

P

Seeded From UniProt

complete

ARATH:CCA23

acts_upstream_of_or_within

GO:0010311: lateral root formation

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G25380

P

Seeded From UniProt

complete

ARATH:CCA23

acts_upstream_of_or_within

GO:0010311: lateral root formation

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G11300

P

Seeded From UniProt

complete

ARATH:CCA23

acts_upstream_of_or_within

GO:0044839: cell cycle G2/M phase transition

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G25380

P

Seeded From UniProt

complete

ARATH:CCA23

acts_upstream_of_or_within

GO:0044839: cell cycle G2/M phase transition

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G11300

P

Seeded From UniProt

complete

ARATH:CCA23

acts_upstream_of_or_within

GO:2000123: positive regulation of stomatal complex development

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G25380

P

Seeded From UniProt

complete

ARATH:CCA23

acts_upstream_of_or_within

GO:2000123: positive regulation of stomatal complex development

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G80370
AGI_LocusCode:AT5G11300

P

Seeded From UniProt

complete

ARATH:MY124

involved_in

GO:0006355: regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:CCA24

acts_upstream_of_or_within

GO:0010389: regulation of G2/M transition of mitotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G15570
AGI_LocusCode:AT5G11300

P

Seeded From UniProt

complete

ARATH:CCA24

acts_upstream_of_or_within

GO:0010374: stomatal complex development

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT5G11300
AGI_LocusCode:AT5G25380

P

Seeded From UniProt

complete

ARATH:CCA24

acts_upstream_of_or_within

GO:0051301: cell division

ECO:0000316: genetic interaction evidence used in manual assertion

AGI_LocusCode:AT5G11300
AGI_LocusCode:AT5G25380

P

Seeded From UniProt

complete


See also

References

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