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PMID:21718540

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Citation

Kivimäe, S, Yang, XY and Cheyette, BN (2011) All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem. 12:33

Abstract

The Dact family of scaffold proteins was discovered by virtue of binding to Dvl proteins central to Wnt and Planar Cell Polarity (PCP) signaling. Subsequently Dact proteins have been linked to a growing list of potential partners implicated in β-catenin-dependent and β-catenin-independent forms of Wnt and other signaling. To clarify conserved and non-conserved roles for this protein family, we systematically compared molecular interactions of all three murine Dact paralogs by co-immunoprecipitation of proteins recombinantly expressed in cultured human embryonic kidney cells.

Links

PubMed PMC3141656 Online version:10.1186/1471-2091-12-33

Keywords

Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Animals; Carrier Proteins/metabolism; Casein Kinase Idelta/metabolism; Casein Kinase Iepsilon/metabolism; Catenins/metabolism; Cell Line; Dimerization; Electrophoresis, Polyacrylamide Gel; Glycogen Synthase Kinase 3/metabolism; Hepatocyte Nuclear Factor 1-alpha/metabolism; Histone Deacetylase 1/metabolism; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Membrane Proteins/metabolism; Mice; Molecular Weight; Nerve Tissue Proteins/metabolism; Phosphoproteins/chemistry; Phosphoproteins/metabolism; Protein Interaction Maps; Protein-Serine-Threonine Kinases/metabolism; Receptors, Transforming Growth Factor beta/metabolism; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; T Cell Transcription Factor 1/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:DVL1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q8R4A3

F

Seeded From UniProt

complete

MOUSE:DACT3

enables

GO:0005080: protein kinase C binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT3

enables

GO:0051018: protein kinase A binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT3

enables

GO:0070097: delta-catenin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT3

enables

GO:0042802: identical protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q0PHV7

F

Seeded From UniProt

complete

MOUSE:DACT3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q7TN08

F

Seeded From UniProt

complete

MOUSE:DACT3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q8R4A3

F

Seeded From UniProt

complete

MOUSE:DVL2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q8R4A3

F

Seeded From UniProt

complete

MOUSE:DACT2

enables

GO:0008013: beta-catenin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT2

enables

GO:0008134: transcription factor binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT2

enables

GO:0005080: protein kinase C binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT2

enables

GO:0051018: protein kinase A binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT2

enables

GO:0070097: delta-catenin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q0PHV7

F

Seeded From UniProt

complete

MOUSE:DACT1

enables

GO:0005080: protein kinase C binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT1

enables

GO:0051018: protein kinase A binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT1

enables

GO:0070097: delta-catenin binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:DACT1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P51141

F

Seeded From UniProt

complete

MOUSE:DACT1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q0PHV7

F

Seeded From UniProt

complete

MOUSE:DACT1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q60838

F

Seeded From UniProt

complete

MOUSE:DACT1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q91ZD4

F

Seeded From UniProt

complete

MOUSE:VANG2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q8R4A3

F

Seeded From UniProt

complete


See also

References

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