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PMID:21679854

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Citation

Caglayan, E, Vantler, M, Leppänen, O, Gerhardt, F, Mustafov, L, Ten Freyhaus, H, Kappert, K, Odenthal, M, Zimmermann, WH, Tallquist, MD and Rosenkranz, S (2011) Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo. J. Am. Coll. Cardiol. 57:2527-38

Abstract

We tested the hypothesis whether selective blunting of platelet-derived growth factor (PDGF)-dependent vascular smooth muscle cell (VSMC) proliferation and migration is sufficient to prevent neointima formation after vascular injury.

Links

PubMed Online version:10.1016/j.jacc.2011.02.037

Keywords

Animals; Cell Movement; Cell Proliferation; Mice; Muscle, Smooth, Vascular/enzymology; Muscle, Smooth, Vascular/pathology; Neointima/prevention & control; Phosphatidylinositol 3-Kinase/metabolism; Phospholipase C gamma/metabolism; Platelet-Derived Growth Factor/metabolism; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PGFRB

involved_in

GO:0070374: positive regulation of ERK1 and ERK2 cascade

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PGFRB

involved_in

GO:0048661: positive regulation of smooth muscle cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PGFRB

involved_in

GO:0014911: positive regulation of smooth muscle cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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