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PMID:21679854
| Citation |
Caglayan, E, Vantler, M, Leppänen, O, Gerhardt, F, Mustafov, L, Ten Freyhaus, H, Kappert, K, Odenthal, M, Zimmermann, WH, Tallquist, MD and Rosenkranz, S (2011) Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo. J. Am. Coll. Cardiol. 57:2527-38 |
|---|---|
| Abstract |
We tested the hypothesis whether selective blunting of platelet-derived growth factor (PDGF)-dependent vascular smooth muscle cell (VSMC) proliferation and migration is sufficient to prevent neointima formation after vascular injury. |
| Links |
PubMed Online version:10.1016/j.jacc.2011.02.037 |
| Keywords |
Animals; Cell Movement; Cell Proliferation; Mice; Muscle, Smooth, Vascular/enzymology; Muscle, Smooth, Vascular/pathology; Neointima/prevention & control; Phosphatidylinositol 3-Kinase/metabolism; Phospholipase C gamma/metabolism; Platelet-Derived Growth Factor/metabolism; Signal Transduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0070374: positive regulation of ERK1 and ERK2 cascade |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048661: positive regulation of smooth muscle cell proliferation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014911: positive regulation of smooth muscle cell migration |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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