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PMID:21625494

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Citation

Köttgen, M, Hofherr, A, Li, W, Chu, K, Cook, S, Montell, C and Watnick, T (2011) Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels. PLoS ONE 6:e20031

Abstract

Sperm have but one purpose, to fertilize an egg. In various species including Drosophila melanogaster female sperm storage is a necessary step in the reproductive process. Amo is a homolog of the human transient receptor potential channel TRPP2 (also known as PKD2), which is mutated in autosomal dominant polycystic kidney disease. In flies Amo is required for sperm storage. Drosophila males with Amo mutations produce motile sperm that are transferred to the uterus but they do not reach the female storage organs. Therefore Amo appears to be a mediator of directed sperm motility in the female reproductive tract but the underlying mechanism is unknown.

Links

PubMed PMC3098850 Online version:10.1371/journal.pone.0020031

Keywords

Amino Acid Sequence; Animals; Drosophila Proteins/chemistry; Drosophila Proteins/physiology; Drosophila melanogaster; Female; Fluorescent Antibody Technique; Genitalia, Female; Humans; Male; Membrane Proteins/chemistry; Membrane Proteins/physiology; Molecular Sequence Data; Sequence Homology, Amino Acid; Sperm Motility; Spermatozoa/physiology; TRPP Cation Channels/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q6T3S5

involved_in

GO:0030317: flagellated sperm motility

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q6T3S5

involved_in

GO:0007283: spermatogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VK95

involved_in

GO:0030317: flagellated sperm motility

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VK95

involved_in

GO:0007283: spermatogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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