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PMID:21616437

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Citation

Loo, YM and Gale, M Jr (2011) Immune signaling by RIG-I-like receptors. Immunity 34:680-92

Abstract

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ligands or processed self RNA in the cytoplasm to trigger innate immunity and inflammation and to impart gene expression that serves to control infection. Importantly, RLRs cooperate in signaling crosstalk networks with Toll-like receptors and other factors to impart innate immunity and to modulate the adaptive immune response. RLR regulation occurs at a variety of levels ranging from autoregulation to ligand and cofactor interactions and posttranslational modifications. Abberant RLR signaling or dysregulation of RLR expression is now implicated in the development of autoimmune diseases. Understanding the processes of RLR signaling and response will provide insights to guide RLR-targeted therapeutics for antiviral and immune-modifying applications.

Links

PubMed PMC3177755 Online version:10.1016/j.immuni.2011.05.003

Keywords

Adaptive Immunity; Animals; DEAD-box RNA Helicases/genetics; DEAD-box RNA Helicases/immunology; DEAD-box RNA Helicases/metabolism; Enzyme Activation; Humans; Immunity, Innate; Signal Transduction; Ubiquitination

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:IFIH1

involved_in

GO:0045087: innate immune response

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DDX58

involved_in

GO:0009615: response to virus

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DDX58

involved_in

GO:0034344: regulation of type III interferon production

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DDX58

involved_in

GO:0039528: cytoplasmic pattern recognition receptor signaling pathway in response to virus

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFIH1

involved_in

GO:0039528: cytoplasmic pattern recognition receptor signaling pathway in response to virus

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFIH1

involved_in

GO:0034344: regulation of type III interferon production

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFIH1

involved_in

GO:0009615: response to virus

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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