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PMID:21596567

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Citation

Singhvi, A, Teuliere, J, Talavera, K, Cordes, S, Ou, G, Vale, RD, Prasad, BC, Clark, SG and Garriga, G (2011) The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions. Curr. Biol. 21:948-54

Abstract

During development, all cells make the decision to live or die. Although the molecular mechanisms that execute the apoptotic program are well defined, less is known about how cells decide whether to live or die. In C. elegans, this decision is linked to how cells divide asymmetrically [1, 2]. Several classes of molecules are known to regulate asymmetric cell divisions in metazoans, yet these molecules do not appear to control C. elegans divisions that produce apoptotic cells [3]. We identified CNT-2, an Arf GTPase-activating protein (GAP) of the AGAP family, as a novel regulator of this type of neuroblast division. Loss of CNT-2 alters daughter cell size and causes the apoptotic cell to adopt the fate of its sister cell, resulting in extra neurons. CNT-2's Arf GAP activity is essential for its function in these divisions. The N terminus of CNT-2, which contains a GTPase-like domain that defines the AGAP class of Arf GAPs, negatively regulates CNT-2's function. We provide evidence that CNT-2 regulates receptor-mediated endocytosis and consider the implications of its role in asymmetric cell divisions.

Links

PubMed PMC3109113 Online version:10.1016/j.cub.2011.04.025

Keywords

ADP-Ribosylation Factor 1/physiology; ADP-Ribosylation Factors/physiology; Animals; Apoptosis; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans Proteins/physiology; Cell Division/physiology; Cell Polarity; Endocytosis/genetics; GTPase-Activating Proteins/genetics; GTPase-Activating Proteins/metabolism; GTPase-Activating Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:ARF12

involved_in

GO:0048259: regulation of receptor-mediated endocytosis

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000566

P

Seeded From UniProt

complete

CAEEL:CNT2

involved_in

GO:0060582: cell fate determination involved in pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00531964

P

Seeded From UniProt

complete

CAEEL:CNT2

involved_in

GO:0048259: regulation of receptor-mediated endocytosis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00531964

P

Seeded From UniProt

complete

CAEEL:CNT2

involved_in

GO:0048259: regulation of receptor-mediated endocytosis

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000182

P

Seeded From UniProt

complete

CAEEL:CNT2

involved_in

GO:0055059: asymmetric neuroblast division

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00531964

P

Seeded From UniProt

complete

CAEEL:CNT2

involved_in

GO:0090630: activation of GTPase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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