GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search

Zenko, M, Zhu, Y, Dremencov, E, Ren, W, Xu, L and Zhang, X (2011) Requirement for the endocannabinoid system in social interaction impairment induced by coactivation of dopamine D1 and D2 receptors in the piriform cortex. J. Neurosci. Res. 89:1245-58


The dopamine receptor family consists of D1-D5 receptors (D1R-D5R), and we explored the contributions of each dopamine receptor subtype in the piriform cortex (PirC) to social interaction impairment (SII). Rats received behavioral tests or electrophysiological recording of PirC neuronal activity after injection of the D1R/D5R agonist SKF38393, the D2R/D3R/D4R agonist quinpirole, or both, with or without pretreatment with dopamine receptor antagonists, D1R or D5R antisense oligonucleotides, the cannabinoid CB1 receptor antagonist AM281, or the endocannabinoid transporter inhibitor VDM11. Systemic injection of SKF38393 and quinpirole together, but not each one alone, induced SII and increased PirC firing rate, which were blocked by D1R or D2R antagonist. Intra-PirC microinfusion of SKF38393 and quinpirole together, but not each one alone, also induced SII, which was blocked by D1R antisense oligonucleotides or D2R antagonist but not by D3R or D4R antagonist or D5R antisense oligonucleotides. SII induced by intra-PirC SKF38393/quinpirole was blocked by AM281 and enhanced by VDM11, whereas neither AM281 nor VDM11 alone affected social interaction behavior. Coadministration of SKF38393 and quinpirole produced anxiolytic effects without significant effects on locomotor activity, olfaction, and acquisition of olfactory short-term memory. These findings suggest that SII induced by coactivation of PirC D1R and D2R requires the endocannabinoid system.


PubMed Online version:10.1002/jnr.22580


2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology; Animals; Behavior, Animal/drug effects; Behavior, Animal/physiology; Cannabinoid Receptor Modulators/metabolism; Cerebral Cortex/drug effects; Cerebral Cortex/metabolism; Dopamine Agonists/pharmacology; Dopamine Antagonists/pharmacology; Endocannabinoids; Male; Morpholines/pharmacology; Neurons/drug effects; Neurons/metabolism; Pyrazoles/pharmacology; Quinpirole/pharmacology; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1/metabolism; Receptors, Dopamine D1/metabolism; Receptors, Dopamine D2/metabolism; Social Behavior



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0035176: social behavior

ECO:0000315: mutant phenotype evidence used in manual assertion


Seeded From UniProt



See also


See Help:References for how to manage references in GONUTS.