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PMID:21507240

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Citation

Liao, M, Zhao, J, Wang, T, Duan, J, Zhang, Y and Deng, X (2011) Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells. Mol. Cancer 10:44

Abstract

Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexpressed in tumor tissues of patients with hepatocellular carcinoma (HCC).

Links

PubMed PMC3107804 Online version:10.1186/1476-4598-10-44

Keywords

Antineoplastic Agents/pharmacology; Apoptosis Regulatory Proteins/metabolism; Carcinogens/pharmacology; Carcinoma, Hepatocellular/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Cisplatin/pharmacology; DNA Damage/drug effects; Drug Resistance, Neoplasm/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Glycochenodeoxycholic Acid/pharmacology; Hep G2 Cells; Humans; Liver Neoplasms/metabolism; Membrane Proteins/metabolism; Mitogen-Activated Protein Kinases/metabolism; Phosphorylation/drug effects; Protein Binding/drug effects; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Ubiquitin-Protein Ligases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:B2L11

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q07820

F

Seeded From UniProt

complete

HUMAN:MCL1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O43521

F

Seeded From UniProt

complete

HUMAN:MCL1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q7Z6Z7

F

Seeded From UniProt

complete

HUMAN:HUWE1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q07820

F

Seeded From UniProt

complete

See also

References

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