PMID:21471512

Citation	Luo, X, Zhang, Y, Ruan, X, Jiang, X, Zhu, L, Wang, X, Ding, Q, Liu, W, Pan, Y, Wang, Z and Chen, Y (2011) Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes 60:1435-45
Abstract	Most animals experience fasting-feeding cycles throughout their lives. It is well known that the liver plays a central role in regulating glycogen metabolism. However, how hepatic glycogenesis is coordinated with the fasting-feeding cycle to control postprandial glucose homeostasis remains largely unknown. This study determines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting-feeding cycle.
Links	PubMed PMC3292316 Online version:10.2337/db10-1663
Keywords	Animals; Blood Glucose/metabolism; Fasting/blood; Fasting/physiology; Hepatocytes/metabolism; Immunoblotting; Immunoprecipitation; Liver/metabolism; Liver Glycogen/biosynthesis; Male; Mice; Mice, Inbred C57BL; Postprandial Period; Protein Phosphatase 1/genetics; Protein Phosphatase 1/metabolism; Reverse Transcriptase Polymerase Chain Reaction
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:PP1A	part_of	GO:0005737: cytoplasm	ECO:0000314: direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
MOUSE:PP1A	part_of	GO:0005634: nucleus	ECO:0000314: direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
MOUSE:PP1A	enables	GO:0005515: protein binding	ECO:0000353: physical interaction evidence used in manual assertion	PR:Q9CW07	F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
MOUSE:PP1A	enables	GO:0005515: protein binding	ECO:0000353: physical interaction evidence used in manual assertion	PR:Q7TMB3	F		Seeded From UniProt	complete
MOUSE:PP1B	part_of	GO:0005737: cytoplasm	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
MOUSE:PP1B	enables	GO:0005515: protein binding	ECO:0000353: physical interaction evidence used in manual assertion	PR:Q9CW07	F		Seeded From UniProt	complete
MOUSE:PPR3C	enables	GO:0019903: protein phosphatase binding	ECO:0000353: physical interaction evidence used in manual assertion	PR:P62137	F		Seeded From UniProt	complete
MOUSE:PP13G	enables	GO:2001069: glycogen binding	ECO:0000314: direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
MOUSE:PP13G	part_of	GO:0005737: cytoplasm	ECO:0000314: direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
MOUSE:PP13G	acts_upstream_of_or_within	GO:2000467: positive regulation of glycogen (starch) synthase activity	ECO:0000314: direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
MOUSE:PP13G	acts_upstream_of_or_within	GO:0042593: glucose homeostasis	ECO:0000314: direct assay evidence used in manual assertion		P	has_participant:(EMAPA:16332)	Seeded From UniProt	complete
MOUSE:PP13G	acts_upstream_of_or_within	GO:0045725: positive regulation of glycogen biosynthetic process	ECO:0000314: direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)|regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
MOUSE:PP13G	enables	GO:0019903: protein phosphatase binding	ECO:0000353: physical interaction evidence used in manual assertion	PR:P62141	F		Seeded From UniProt	complete
MOUSE:PP13G	enables	GO:0019903: protein phosphatase binding	ECO:0000353: physical interaction evidence used in manual assertion	PR:P62137	F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
MOUSE:PP13G	acts_upstream_of_or_within	GO:2000467: positive regulation of glycogen (starch) synthase activity	ECO:0000315: mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
MOUSE:PP13G	acts_upstream_of_or_within	GO:0042593: glucose homeostasis	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:16846)	Seeded From UniProt	complete
MOUSE:PP13G	acts_upstream_of_or_within	GO:0045725: positive regulation of glycogen biosynthetic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete

References

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