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PMID:21471512

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Citation

Luo, X, Zhang, Y, Ruan, X, Jiang, X, Zhu, L, Wang, X, Ding, Q, Liu, W, Pan, Y, Wang, Z and Chen, Y (2011) Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes 60:1435-45

Abstract

Most animals experience fasting-feeding cycles throughout their lives. It is well known that the liver plays a central role in regulating glycogen metabolism. However, how hepatic glycogenesis is coordinated with the fasting-feeding cycle to control postprandial glucose homeostasis remains largely unknown. This study determines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting-feeding cycle.

Links

PubMed PMC3292316 Online version:10.2337/db10-1663

Keywords

Animals; Blood Glucose/metabolism; Fasting/blood; Fasting/physiology; Hepatocytes/metabolism; Immunoblotting; Immunoprecipitation; Liver/metabolism; Liver Glycogen/biosynthesis; Male; Mice; Mice, Inbred C57BL; Postprandial Period; Protein Phosphatase 1/genetics; Protein Phosphatase 1/metabolism; Reverse Transcriptase Polymerase Chain Reaction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PP1A

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000182)

Seeded From UniProt

complete

MOUSE:PP1A

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000182)

Seeded From UniProt

complete

MOUSE:PP1A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:Q9CW07

F

  • occurs_in:(EMAPA:16846)

Seeded From UniProt

complete

MOUSE:PP1A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:Q7TMB3

F

Seeded From UniProt

complete

MOUSE:PP1B

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:PP1B

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:Q9CW07

F

Seeded From UniProt

complete

MOUSE:PPR3C

enables

GO:0019903: protein phosphatase binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P62137

F

Seeded From UniProt

complete

MOUSE:PP13G

enables

GO:2001069: glycogen binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:PP13G

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000182)

Seeded From UniProt

complete

MOUSE:PP13G

acts_upstream_of_or_within

GO:2000467: positive regulation of glycogen (starch) synthase activity

ECO:0000314: direct assay evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:16846)

Seeded From UniProt

complete

MOUSE:PP13G

acts_upstream_of_or_within

GO:0042593: glucose homeostasis

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_participant:(EMAPA:16332)

Seeded From UniProt

complete

MOUSE:PP13G

acts_upstream_of_or_within

GO:0045725: positive regulation of glycogen biosynthetic process

ECO:0000314: direct assay evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:16846)|regulates_o_occurs_in:(CL:0000182)

Seeded From UniProt

complete

MOUSE:PP13G

enables

GO:0019903: protein phosphatase binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P62141

F

Seeded From UniProt

complete

MOUSE:PP13G

enables

GO:0019903: protein phosphatase binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P62137

F

  • occurs_in:(EMAPA:16846)

Seeded From UniProt

complete

MOUSE:PP13G

acts_upstream_of_or_within

GO:2000467: positive regulation of glycogen (starch) synthase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:16846)

Seeded From UniProt

complete

MOUSE:PP13G

acts_upstream_of_or_within

GO:0042593: glucose homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_participant:(EMAPA:16846)

Seeded From UniProt

complete

MOUSE:PP13G

acts_upstream_of_or_within

GO:0045725: positive regulation of glycogen biosynthetic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:16846)

Seeded From UniProt

complete


See also

References

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