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PMID:21455291

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Citation

Bang, S, Hyun, S, Hong, ST, Kang, J, Jeong, K, Park, JJ, Choe, J and Chung, J (2011) Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila. PLoS Genet. 7:e1001346

Abstract

The ability to respond to environmental temperature variation is essential for survival in animals. Flies show robust temperature-preference behaviour (TPB) to find optimal temperatures. Recently, we have shown that Drosophila mushroom body (MB) functions as a center controlling TPB. However, neuromodulators that control the TPB in MB remain unknown. To identify the functions of dopamine in TPB, we have conducted various genetic studies in Drosophila. Inhibition of dopamine biosynthesis by genetic mutations or treatment with chemical inhibitors caused flies to prefer temperatures colder than normal. We also found that dopaminergic neurons are involved in TPB regulation, as the targeted inactivation of dopaminergic neurons by expression of a potassium channel (Kir2.1) induced flies with the loss of cold avoidance. Consistently, the mutant flies for dopamine receptor gene (DopR) also showed a cold temperature preference, which was rescued by MB-specific expression of DopR. Based on these results, we concluded that dopamine in MB is a key component in the homeostatic temperature control of Drosophila. The current findings will provide important bases to understand the logic of thermosensation and temperature preference decision in Drosophila.

Links

PubMed PMC3063753 Online version:10.1371/journal.pgen.1001346

Keywords

Animals; Behavior, Animal/physiology; Body Temperature Regulation/genetics; Brain/metabolism; Cold Temperature; Dopamine/metabolism; Drosophila/genetics; Drosophila/metabolism; Drosophila/physiology; Gene Expression Regulation/genetics; Mushroom Bodies/metabolism; Mutation/genetics; Neurons/metabolism; Receptors, Dopamine/genetics; Receptors, Dopamine/metabolism; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:DDC

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DDC

involved_in

GO:0040040: thermosensory behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TY3H

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TY3H

involved_in

GO:0040040: thermosensory behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DOPR1

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DOPR1

involved_in

GO:0040040: thermosensory behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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