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PMID:21401944

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Citation

Holtz, ML and Misra, RP (2011) Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium. BMC Dev. Biol. 11:18

Abstract

Endothelial-specific knockout of the transcription factor serum response factor (SRF) results in embryonic lethality by mid-gestation. The associated phenotype exhibits vascular failure in embryos as well as visceral yolk sac (VYS) tissues. Previous data suggest that this vascular failure is caused by alterations in cell-cell and cell-matrix contacts. In the current study, we sought to more carefully address the role of SRF in endothelial function and cell contact interactions in VYS tissues.

Links

PubMed PMC3065428 Online version:10.1186/1471-213X-11-18

Keywords

Actins/genetics; Actins/metabolism; Animals; Antigens, CD/genetics; Antigens, CD29/genetics; Blood Vessels/embryology; Blood Vessels/metabolism; Cadherins/genetics; Cell Adhesion; Cell Proliferation; Cell-Matrix Junctions/physiology; Embryo, Mammalian/metabolism; Endothelial Cells/cytology; Endothelial Cells/metabolism; Endothelium, Vascular/embryology; Endothelium, Vascular/metabolism; Fibronectins/genetics; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Integrin alpha5/genetics; Membrane Proteins/genetics; Mesoderm/cytology; Mesoderm/embryology; Mesoderm/metabolism; Mice; Mice, Transgenic; Polymerase Chain Reaction; Receptor, TIE-2/genetics; Serum Response Factor/genetics; Serum Response Factor/metabolism; Signal Transduction; Yolk Sac/blood supply; Yolk Sac/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SRF

acts_upstream_of_or_within

GO:0007160: cell-matrix adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2450311,MGI:MGI:3522206

P

  • occurs_in:(EMAPA:16039)

Seeded From UniProt

complete

MOUSE:SRF

acts_upstream_of_or_within

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2450311,MGI:MGI:3522206

P

  • occurs_in:(CL:0000115)
  • occurs_in:(EMAPA:16039)

Seeded From UniProt

complete


See also

References

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