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PMID:21368042

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Citation

Ye, B, Kim, JH, Yang, L, McLachlan, I, Younger, S, Jan, LY and Jan, YN (2011) Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1. J. Neurosci. 31:3309-19

Abstract

Dendrites and axons are two major neuronal compartments with differences that are critical for neuronal functions. To learn about the differential regulation of dendritic and axonal development, we conducted a genetic screen in Drosophila and isolated the dendritic arbor reduction 1 (dar1) mutants, which display defects in dendritic but not axonal growth. The dar1 gene encodes a novel transcription regulator in the Krüppel-like factor family. Neurons lacking dar1 function have severely reduced growth of microtubule- but not F-actin-based dendritic branches. In contrast, overexpression of Dar1 dramatically increased the growth of microtubule-based dendritic branches. Our results suggest that Dar1 promotes dendrite growth in part by suppressing the expression of the microtubule-severing protein Spastin. Our study thus uncovers a novel transcriptional program for microtubule regulation that preferentially controls dendrite growth.

Links

PubMed PMC3086283 Online version:10.1523/JNEUROSCI.6307-10.2011

Keywords

Adenosine Triphosphatases/antagonists & inhibitors; Adenosine Triphosphatases/biosynthesis; Adenosine Triphosphatases/genetics; Animals; Animals, Genetically Modified; Axons/physiology; Axons/ultrastructure; Dendrites/physiology; Dendrites/ultrastructure; Drosophila Proteins/antagonists & inhibitors; Drosophila Proteins/biosynthesis; Drosophila Proteins/deficiency; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Drosophila melanogaster; Female; Kruppel-Like Transcription Factors/deficiency; Kruppel-Like Transcription Factors/genetics; Kruppel-Like Transcription Factors/physiology; Male; Receptors, G-Protein-Coupled/deficiency; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/physiology; Receptors, Neuropeptide/deficiency; Receptors, Neuropeptide/genetics; Receptors, Neuropeptide/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:SPAST

involved_in

GO:0050775: positive regulation of dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DAR1

involved_in

GO:0000122: negative regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DAR1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:DAR1

involved_in

GO:0007026: negative regulation of microtubule depolymerization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DAR1

involved_in

GO:0006357: regulation of transcription by RNA polymerase II

ECO:0000250: sequence similarity evidence used in manual assertion

MGI:MGI:1338056

P

Seeded From UniProt

complete

DROME:DAR1

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000250: sequence similarity evidence used in manual assertion

MGI:MGI:1338056

F

Seeded From UniProt

complete

DROME:DAR1

involved_in

GO:0050775: positive regulation of dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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