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PMID:21366928

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Citation

Brideau, NJ and Barbash, DA (2011) Functional conservation of the Drosophila hybrid incompatibility gene Lhr. BMC Evol. Biol. 11:57

Abstract

Hybrid incompatibilities such as sterility and lethality are commonly modeled as being caused by interactions between two genes, each of which has diverged separately in one of the hybridizing lineages. The gene Lethal hybrid rescue (Lhr) encodes a rapidly evolving heterochromatin protein that causes lethality of hybrid males in crosses between Drosophila melanogaster females and D. simulans males. Previous genetic analyses showed that hybrid lethality is caused by D. simulans Lhr but not by D. melanogaster Lhr, confirming a critical prediction of asymmetry in the evolution of a hybrid incompatibility gene.

Links

PubMed PMC3060119 Online version:10.1186/1471-2148-11-57

Keywords

Animals; Chromosomal Proteins, Non-Histone/metabolism; Cloning, Molecular; Conserved Sequence; Crosses, Genetic; Drosophila/genetics; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Evolution, Molecular; Female; Genes, Insect; Genes, Lethal; Heterochromatin/metabolism; Male; Mutagenesis, Site-Directed; Protein Binding; Protein Interaction Domains and Motifs; Sequence Analysis, DNA; Two-Hybrid System Techniques

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q95RV3

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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