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PMID:21345313

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Citation

Han, S, Koo, J, Bae, J, Kim, S, Baik, S and Kim, MY (2011) Modulation of TNFSF expression in lymphoid tissue inducer cells by dendritic cells activated with Toll-like receptor ligands. BMB Rep 44:129-34

Abstract

Toll-like receptors (TLRs), which recognize structurally conserved components among pathogens, are mainly expressed by antigen-presenting cells such as dendritic cells (DCs), B cells, and macrophages. Recognition through TLRs triggers innate immune responses and influences antigen-specific adaptive immune responses. Although studies on the expression and functions of TLRs in antigen-presenting cells have been extensively reported, studies in lymphoid tissue inducer (LTi) cells have been limited. In this study, we observed that LTi cells expressed TLR2 and TLR4 mRNA as well as TLR2 protein and upregulated OX40L, CD30L, and TRANCE expression after stimulation with the TLR2 ligand zymosan or TLR4 ligand LPS. The expression of tumor necrosis factor superfamily (TNFSF) members was significantly upregulated when cells were cocultured with DCs, suggesting that upregulated TNFSF expression may contribute to antigen-specific adaptive immune responses.

Links

PubMed Online version:10.5483/BMBRep.2011.44.2.129

Keywords

Animals; CD30 Ligand/genetics; CD30 Ligand/metabolism; Cells, Cultured; Coculture Techniques; Dendritic Cells/drug effects; Dendritic Cells/immunology; Dendritic Cells/metabolism; Ligands; Lipopolysaccharides/pharmacology; Lymphoid Tissue/cytology; Lymphoid Tissue/immunology; Mice; Mice, Inbred C57BL; OX40 Ligand/genetics; OX40 Ligand/metabolism; RANK Ligand/genetics; RANK Ligand/metabolism; Toll-Like Receptor 2/antagonists & inhibitors; Toll-Like Receptor 2/genetics; Toll-Like Receptor 2/metabolism; Toll-Like Receptor 4/antagonists & inhibitors; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism; Tumor Necrosis Factors/genetics; Tumor Necrosis Factors/metabolism; Up-Regulation; Zymosan/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:TNFL4

involved_in

GO:0071222: cellular response to lipopolysaccharide

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete


See also

References

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