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PMID:21248138

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Citation

King, I, Tsai, LT, Pflanz, R, Voigt, A, Lee, S, Jäckle, H, Lu, B and Heberlein, U (2011) Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. J. Neurosci. 31:1139-48

Abstract

In both mammalian and insect models of ethanol-induced behavior, low doses of ethanol stimulate locomotion. However, the mechanisms of the stimulant effects of ethanol on the CNS are mostly unknown. We have identified tao, encoding a serine-threonine kinase of the Ste20 family, as a gene necessary for ethanol-induced locomotor hyperactivity in Drosophila. Mutations in tao also affect behavioral responses to cocaine and nicotine, making flies resistant to the effects of both drugs. We show that tao function is required during the development of the adult nervous system and that tao mutations cause defects in the development of central brain structures, including the mushroom body. Silencing of a subset of mushroom body neurons is sufficient to reduce ethanol-induced hyperactivity, revealing the mushroom body as an important locus mediating the stimulant effects of ethanol. We also show that mutations in par-1 suppress both the mushroom body morphology and behavioral phenotypes of tao mutations and that the phosphorylation state of the microtubule-binding protein Tau can be altered by RNA interference knockdown of tao, suggesting that tao and par-1 act in a pathway to control microtubule dynamics during neural development.

Links

PubMed PMC3045818 Online version:10.1523/JNEUROSCI.4416-10.2011

Keywords

Analysis of Variance; Animals; Behavior, Animal/drug effects; Behavior, Animal/physiology; Blotting, Western; Drosophila; Drosophila Proteins/metabolism; Ethanol/pharmacology; Hyperkinesis/chemically induced; Hyperkinesis/metabolism; Immunohistochemistry; Metamorphosis, Biological; Motor Activity/drug effects; Motor Activity/physiology; Mushroom Bodies/drug effects; Mushroom Bodies/metabolism; Neurons/metabolism; Protein-Serine-Threonine Kinases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:TAO

involved_in

GO:0042220: response to cocaine

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TAO

involved_in

GO:0016319: mushroom body development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TAO

involved_in

GO:0035094: response to nicotine

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TAO

involved_in

GO:0045471: response to ethanol

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TAO

involved_in

GO:0048036: central complex development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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