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Song, JK and Giniger, E (2011) Noncanonical Notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of Trio. Dev. Dyn. 240:324-32


The receptor Notch interacts with the Abl tyrosine kinase signaling pathway to control axon growth and guidance in Drosophila motor neurons. In part, this is mediated by binding to Trio, a guanine nucleotide exchange factor (GEF) for Rho GTPases. We show here that one of the two GEF domains of Trio, the Rac-specific GEF1, is essential for Trio-dependent motor axon guidance and for the genetic suppression of Notch function in motor axon patterning, but the Rho-specific GEF2 domain is not. Consistent with this, we show that Rac, and not Rho1 or Cdc42, interacts genetically with Notch in a manner indistinguishable from that of bona fide Abl signaling components. We infer, therefore, that Rac is a key component of Abl signaling in Drosophila motor axons, and specifically that it is the crucial Rho GTPase in "noncanonical" Notch/Abl signaling.


PubMed PMC3070923 Online version:10.1002/dvdy.22525


Animals; Axons/physiology; Axons/ultrastructure; Cell Movement/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/physiology; Guanine Nucleotide Exchange Factors/genetics; Guanine Nucleotide Exchange Factors/metabolism; Motor Neurons/cytology; Motor Neurons/physiology; Phosphoproteins/genetics; Phosphoproteins/metabolism; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Receptors, Notch/genetics; Receptors, Notch/metabolism; Signal Transduction/physiology; rac GTP-Binding Proteins/genetics; rac GTP-Binding Proteins/metabolism



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0008045: motor neuron axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion


Seeded From UniProt


See also


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