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PMID:21164016

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Citation

Chen, S, Zhang, YE and Long, M (2010) New genes in Drosophila quickly become essential. Science 330:1682-5

Abstract

To investigate the origin and evolution of essential genes, we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for viability. The proportion of genes that are essential is similar in every evolutionary age group that we examined. Under constitutive silencing of these young essential genes, lethality was high in the pupal stage and also found in the larval stages. Lethality was attributed to diverse cellular and developmental defects, such as organ formation and patterning defects. These data suggest that new genes frequently and rapidly evolve essential functions and participate in development.

Links

PubMed Online version:10.1126/science.1196380

Keywords

Amino Acid Substitution; Animals; Body Patterning/genetics; Drosophila/classification; Drosophila/genetics; Drosophila/growth & development; Drosophila Proteins/chemistry; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Drosophila melanogaster/classification; Drosophila melanogaster/genetics; Drosophila melanogaster/growth & development; Evolution, Molecular; Gene Duplication; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Essential; Genes, Insect; Larva/genetics; Larva/growth & development; Metamorphosis, Biological; Phenotype; Phylogeny; Pupa/genetics; Pupa/growth & development; RNA Interference; Time Factors; Wing/abnormalities; Wing/growth & development

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:E1JIB3

involved_in

GO:0022416: chaeta development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:E1JIB3

involved_in

GO:0007477: notum development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:M9PH04

involved_in

GO:0022416: chaeta development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:M9PH04

involved_in

GO:0007477: notum development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IHD1

involved_in

GO:0048802: notum morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8INM1

involved_in

GO:0048802: notum morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8INM2

involved_in

GO:0048802: notum morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VAB9

involved_in

GO:0035220: wing disc development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CP9F2

involved_in

GO:0035220: wing disc development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W037

involved_in

GO:0022416: chaeta development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W037

involved_in

GO:0007477: notum development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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