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PMID:21129186

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Citation

Jouvet, N, Poschmann, J, Douville, J, Bulet, L and Ramotar, D (2010) Rrd1 isomerizes RNA polymerase II in response to rapamycin. BMC Mol. Biol. 11:92

Abstract

In Saccharomyces cerevisiae, the immunosuppressant rapamycin engenders a profound modification in the transcriptional profile leading to growth arrest. Mutants devoid of Rrd1, a protein possessing in vitro peptidyl prolyl cis/trans isomerase activity, display striking resistance to the drug, although how Rrd1 activity is linked to the biological responses has not been elucidated.

Links

PubMed PMC3019149 Online version:10.1186/1471-2199-11-92

Keywords

Chromatin/metabolism; Circular Dichroism; Intracellular Signaling Peptides and Proteins/metabolism; Isomerism; Peptidylprolyl Isomerase/metabolism; Phosphorylation; Protein Structure, Tertiary; Protein Subunits/chemistry; Protein Subunits/metabolism; RNA Polymerase II/chemistry; RNA Polymerase II/metabolism; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Sirolimus/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

YEAST:PTPA1

colocalizes_with

GO:0000785: chromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

YEAST:PTPA1

involved_in

GO:0043618: regulation of transcription from RNA polymerase II promoter in response to stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:PTPA1

involved_in

GO:0043618: regulation of transcription from RNA polymerase II promoter in response to stress

ECO:0000353: physical interaction evidence used in manual assertion

SGD:S000002299

P

Seeded From UniProt

complete


See also

References

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