GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:21061380

From GONUTS
Jump to: navigation, search
Citation

Li, S, Yin, M, Liu, S, Chen, Y, Yin, Y, Liu, T and Zhou, J (2010) Expression of ventral diencephalon-enriched genes in zebrafish. Dev. Dyn. 239:3368-79

Abstract

Dopaminergic (DA) neurons in the vertebrate di- and mesencephalon play essential roles in movement control, endocrine modulation and many other important physiological activities. To identify genes that may regulate the specification and differentiation of diencephalic DA neurons in zebrafish, the spatial and temporal expression pattern of a set of genes was investigated. In situ hybridization analysis revealed that expression of DNA binding inhibitor 3 (Id3), early B cell factor 2 (Ebf2), Ebf3, Iroquois related homeobox 1 (Irx1), Kruppel-like factor 7 (Klf7), mab-21-like 1 (Mab21l1), fatty acid binding protein 7 (Fabp7) and stathmin-like 4 (Stmn4), were enriched in the diencephalon of zebrafish. Among these genes, Id3 was expressed specifically in a subset of DA neurons in the ventral diencephalon, with co-expression of neurogenin1 (Ngn1). Alteration of expression levels of Id3 inhibited maturation of developing DA neurons. Taken together, our study provides genetic characteristics of DA neurons in the diencephalon of zebrafish.

Links

PubMed Online version:10.1002/dvdy.22467

Keywords

Animals; Diencephalon/embryology; Diencephalon/metabolism; Dopamine/metabolism; Embryo, Nonmammalian/metabolism; Fatty Acid-Binding Proteins/genetics; Fatty Acid-Binding Proteins/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; In Situ Hybridization; Inhibitor of Differentiation Proteins/genetics; Inhibitor of Differentiation Proteins/metabolism; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Zebrafish; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:Q8QFX4

involved_in

GO:0071542: dopaminergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101210-3

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.