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PMID:21048033

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Citation

Cvejic, A, Serbanovic-Canic, J, Stemple, DL and Ouwehand, WH (2011) The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. Haematologica 96:190-8

Abstract

The Meis1 protein represents an important cofactor for Hox and Pbx1 and is implicated in human and murine leukemias. Though much is known about the role of meis1 in leukemogenesis, its function in normal hematopoiesis remains largely unclear. Here we characterized the role of the proto-oncogene, meis1, during zebrafish primitive and definitive hematopoiesis.

Links

PubMed PMC3031685 Online version:10.3324/haematol.2010.027698

Keywords

Animals; Cell Differentiation; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/metabolism; Erythrocytes/cytology; Erythrocytes/metabolism; Gene Expression Regulation, Developmental; Hematopoiesis/physiology; Homeodomain Proteins/physiology; Immunoenzyme Techniques; In Situ Hybridization, Fluorescence; Macrophages/metabolism; Neoplasm Proteins/physiology; Neutrophils/metabolism; Transcription Factors/metabolism; Zebrafish/genetics; Zebrafish/growth & development; Zebrafish/metabolism; Zebrafish Proteins/metabolism; Zebrafish Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:Q7ZW49

involved_in

GO:0030223: neutrophil differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q7ZW49

involved_in

GO:0001944: vasculature development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q7ZW49

involved_in

GO:0060216: definitive hemopoiesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0030225: macrophage differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0030223: neutrophil differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DANRE:Q90XH2

located_in

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0060841: venous blood vessel development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0060319: primitive erythrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0060216: definitive hemopoiesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0072554: blood vessel lumenization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0045766: positive regulation of angiogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0035907: dorsal aorta development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XH2

involved_in

GO:0035476: angioblast cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q9I9B6

involved_in

GO:0030223: neutrophil differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q9I9B6

involved_in

GO:0001944: vasculature development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q9I9B6

involved_in

GO:0060216: definitive hemopoiesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q9I9B7

involved_in

GO:0030223: neutrophil differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q9I9B7

involved_in

GO:0001944: vasculature development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete

DANRE:Q9I9B7

involved_in

GO:0060216: definitive hemopoiesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110216-2

P

Seeded From UniProt

complete


See also

References

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