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PMID:20977703

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Citation

Poulin, GB and Ahringer, J (2010) The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells. BMC Dev. Biol. 10:109

Abstract

Attenuation of the EGFR (Epidermal Growth Factor Receptor) signalling cascade is crucial to control cell fate during development. A candidate-based RNAi approach in C. elegans identified CDT-2 as an attenuator of LET-23 (EGFR) signalling. Human CDT2 is a component of the conserved CDT2/CUL4/DDB1 ubiquitin ligase complex that plays a critical role in DNA replication and G2/M checkpoint. Within this complex, CDT2 is responsible for substrate recognition. This ubiquitin ligase complex has been shown in various organisms, including C. elegans, to target the replication-licensing factor CDT1, and the CDK inhibitor p21. However, no previous link to EGFR signalling has been identified.

Links

PubMed PMC2984460 Online version:10.1186/1471-213X-10-109

Keywords

Animals; Animals, Genetically Modified; Caenorhabditis elegans/anatomy & histology; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Endocytosis/physiology; Epistasis, Genetic; Female; Gene Deletion; Humans; Ligases/genetics; Ligases/metabolism; RNA Interference; Receptor, Epidermal Growth Factor/genetics; Receptor, Epidermal Growth Factor/metabolism; Receptors, Notch/genetics; Receptors, Notch/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Signal Transduction/physiology; Stem Cells/cytology; Stem Cells/physiology; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism; Vulva/anatomy & histology; Vulva/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:Q22059

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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