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PMID:20940230

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Citation

Song, JK, Kannan, R, Merdes, G, Singh, J, Mlodzik, M and Giniger, E (2010) Disabled is a bona fide component of the Abl signaling network. Development 137:3719-27

Abstract

Abl is an essential regulator of cell migration and morphogenesis in both vertebrates and invertebrates. It has long been speculated that the adaptor protein Disabled (Dab), which is a key regulator of neuronal migration in the vertebrate brain, might be a component of this signaling pathway, but this idea has been controversial. We now demonstrate that null mutations of Drosophila Dab result in phenotypes that mimic Abl mutant phenotypes, both in axon guidance and epithelial morphogenesis. The Dab mutant interacts genetically with mutations in Abl, and with mutations in the Abl accessory factors trio and enabled (ena). Genetic epistasis tests show that Dab functions upstream of Abl and ena, and, consistent with this, we show that Dab is required for the subcellular localization of these two proteins. We therefore infer that Dab is a bona fide component of the core Abl signaling pathway in Drosophila.

Links

PubMed PMC2964101 Online version:10.1242/dev.050948

Keywords

Animals; Animals, Genetically Modified; Cell Movement/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila/embryology; Drosophila/genetics; Drosophila/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Embryo, Nonmammalian; Epistasis, Genetic; Female; Gene Regulatory Networks/genetics; Gene Regulatory Networks/physiology; Models, Biological; Motor Neurons/metabolism; Motor Neurons/physiology; Mutation/physiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nerve Tissue Proteins/physiology; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; Protein-Tyrosine Kinases/physiology; Signal Transduction/genetics; Signal Transduction/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:DAB

involved_in

GO:0007391: dorsal closure

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DAB

involved_in

GO:0007349: cellularization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DAB

involved_in

GO:0008045: motor neuron axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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