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PMID:20860823

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Citation

Wong, L, Weadick, CJ, Kuo, C, Chang, BS and Tropepe, V (2010) Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC Dev. Biol. 10:100

Abstract

The Dmbx1 gene is important for the development of the midbrain and hindbrain, and mouse gene targeting experiments reveal that this gene is required for mediating postnatal and adult feeding behaviours. A single Dmbx1 gene exists in terrestrial vertebrate genomes, while teleost genomes have at least two paralogs. We compared the loss of function of the zebrafish dmbx1a and dmbx1b genes in order to gain insight into the molecular mechanism by which dmbx1 regulates neurogenesis, and to begin to understand why these duplicate genes have been retained in the zebrafish genome.

Links

PubMed PMC2954992 Online version:10.1186/1471-213X-10-100

Keywords

Animals; Animals, Genetically Modified; Cell Cycle/physiology; Cell Differentiation/physiology; Embryo, Nonmammalian/anatomy & histology; Embryo, Nonmammalian/pathology; Embryo, Nonmammalian/physiology; Evolution, Molecular; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Mesencephalon/embryology; Mesencephalon/growth & development; Mesencephalon/pathology; Mice; Neurogenesis/physiology; Oligonucleotides, Antisense/genetics; Oligonucleotides, Antisense/metabolism; Otx Transcription Factors/genetics; Otx Transcription Factors/metabolism; Protein Isoforms/genetics; Protein Isoforms/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Retina/embryology; Retina/growth & development; Retina/pathology; Stem Cells/cytology; Stem Cells/physiology; Transcription Factors/genetics; Transcription Factors/metabolism; Zebrafish/anatomy & histology; Zebrafish/embryology; Zebrafish/growth & development; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:DMX1B

involved_in

GO:0030901: midbrain development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101027-2

P

Seeded From UniProt

complete

DANRE:DMX1B

involved_in

GO:0051726: regulation of cell cycle

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101027-2

P

Seeded From UniProt

complete

DANRE:DMX1B

involved_in

GO:0050767: regulation of neurogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101027-2

P

Seeded From UniProt

complete

DANRE:DMX1B

involved_in

GO:0050767: regulation of neurogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101027-2

P

Seeded From UniProt

complete

DANRE:DMX1B

involved_in

GO:0050767: regulation of neurogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100412-1

P

Seeded From UniProt

complete

DANRE:DMX1B

involved_in

GO:0060041: retina development in camera-type eye

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101027-2

P

Seeded From UniProt

complete

DANRE:DMX1A

involved_in

GO:0030901: midbrain development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100412-1

P

Seeded From UniProt

complete

DANRE:DMX1A

involved_in

GO:0051726: regulation of cell cycle

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100412-1

P

Seeded From UniProt

complete

DANRE:DMX1A

involved_in

GO:0050767: regulation of neurogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100412-1

P

Seeded From UniProt

complete

DANRE:DMX1A

involved_in

GO:0050767: regulation of neurogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100412-1,ZFIN:ZDB-MRPHLNO-101027-2

P

Seeded From UniProt

complete

DANRE:DMX1A

involved_in

GO:0060041: retina development in camera-type eye

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100412-1

P

Seeded From UniProt

complete


See also

References

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