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PMID:20731842

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Citation

Li, YF, He, W, Kim, YH, Mandal, A, Digilio, L, Klotz, K, Flickinger, CJ and Herr, JC (2010) CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Reprod. Biol. Endocrinol. 8:101

Abstract

CABYR is a polymorphic calcium-binding protein of the sperm fibrous sheath (FS) which gene contains two coding regions (CR-A and CR-B) and is tyrosine as well as serine/threonine phosphorylated during in vitro sperm capacitation. Thus far, the detailed information on CABYR protein expression in mouse spermatogenesis is lacking. Moreover, because of the complexity of this polymorphic protein, there are no data on how CABYR isoforms associate and assemble into the FS.

Links

PubMed PMC3398308 Online version:10.1186/1477-7827-8-101

Keywords

A Kinase Anchor Proteins/genetics; A Kinase Anchor Proteins/metabolism; Animals; Calcium-Binding Proteins/chemistry; Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/metabolism; Male; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Mice, Inbred ICR; Phosphoproteins/chemistry; Phosphoproteins/genetics; Phosphoproteins/metabolism; Protein Binding; Protein Interaction Domains and Motifs/physiology; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Isoforms/metabolism; Protein Multimerization/physiology; Sperm Capacitation/physiology; Sperm Tail/metabolism; Sperm Tail/ultrastructure; Spermatogenesis/genetics; Spermatogenesis/physiology; Spermatozoa/metabolism; Spermatozoa/physiology; Spermatozoa/ultrastructure; Time Factors; rho GTP-Binding Proteins/genetics; rho GTP-Binding Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:AKAP3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9D424

F

Seeded From UniProt

complete

MOUSE:AKAP4

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9D424

F

Seeded From UniProt

complete

MOUSE:CABYR

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:O88987
PR:Q60662
PR:Q9ESG2

F

Seeded From UniProt

complete

MOUSE:CABYR

involved_in

GO:0019722: calcium-mediated signaling

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CABYR

enables

GO:0019904: protein domain specific binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q60662

F

Seeded From UniProt

complete

MOUSE:CABYR

enables

GO:0019904: protein domain specific binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O88987

F

Seeded From UniProt

complete

MOUSE:CABYR

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:CABYR

located_in

GO:0035686: sperm fibrous sheath

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:CABYR

involved_in

GO:0048240: sperm capacitation

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ROP1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:Q9D424

F

Seeded From UniProt

complete


See also

References

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