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PMID:20689587

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Citation

Fett, ME, Pilsl, A, Paquet, D, van Bebber, F, Haass, C, Tatzelt, J, Schmid, B and Winklhofer, KF (2010) Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS ONE 5:e11783

Abstract

Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial neuropathological or behavioral phenotype, while loss of parkin in Drosophila melanogaster leads to a severe phenotype, including reduced lifespan, apoptotic flight muscle degeneration and male sterility. In order to study the function of parkin in more detail and to address possible differences in its role in different species, we chose Danio rerio as a different vertebrate model system.

Links

PubMed PMC2912770 Online version:10.1371/journal.pone.0011783

Keywords

Animals; Animals, Genetically Modified; Apoptosis/genetics; Apoptosis/physiology; Blotting, Western; Cell Line; Cell Line, Tumor; Dopamine/metabolism; Female; Fluorescent Antibody Technique, Indirect; HeLa Cells; Humans; In Situ Hybridization; Male; Membrane Potential, Mitochondrial/genetics; Membrane Potential, Mitochondrial/physiology; Neurons/metabolism; Polymerase Chain Reaction; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism; Zebrafish/genetics; Zebrafish/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A0H2UKX4

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DANRE:A0A0H2UKX4

involved_in

GO:0006979: response to oxidative stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A0A0H2UKX4

involved_in

GO:0009266: response to temperature stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A0A0H2UKX4

involved_in

GO:0051865: protein autoubiquitination

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A0A0H2UKX4

involved_in

GO:0042981: regulation of apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A5WUG4

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DANRE:A5WUG4

involved_in

GO:0006979: response to oxidative stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A5WUG4

involved_in

GO:0009266: response to temperature stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A5WUG4

involved_in

GO:0051865: protein autoubiquitination

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A5WUG4

involved_in

GO:0042981: regulation of apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:F1Q9C4

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DANRE:F1Q9C4

involved_in

GO:0006979: response to oxidative stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:F1Q9C4

involved_in

GO:0009266: response to temperature stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:F1Q9C4

involved_in

GO:0051865: protein autoubiquitination

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:F1Q9C4

involved_in

GO:0042981: regulation of apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q561U2

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DANRE:Q561U2

involved_in

GO:0006979: response to oxidative stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q561U2

involved_in

GO:0009266: response to temperature stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q561U2

involved_in

GO:0051865: protein autoubiquitination

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q561U2

involved_in

GO:0042981: regulation of apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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