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PMID:20675388

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Citation

Yan, W, Si, Y, Slaymaker, S, Li, J, Zheng, H, Young, DL, Aslanian, A, Saunders, L, Verdin, E and Charo, IF (2010) Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J. Biol. Chem. 285:31418-26

Abstract

Spermatogenesis is a complex process through which male germ line stem cells undergo a multi-step differentiation program and sequentially become spermatogonia, spermatocytes, spermatids, and eventually spermatozoa. In this process, transcription factors act as switches that precisely regulate the expression of genes that in turn control the developmental program of male germ cells. Transcription factors identified to be essential for normal haploid gene expression all display transcription-activating effects and thus serve as the "on" switch for haploid gene expression. Here, we report that ZMYND15 acts as a histone deacetylase-dependent transcriptional repressor and controls normal temporal expression of haploid cell genes during spermiogenesis. Inactivation of Zmynd15 results in early activation of transcription of numerous important haploid genes including Prm1, Tnp1, Spem1, and Catpser3; depletion of late spermatids; and male infertility. ZMYND15 represents the first transcriptional repressor identified to be essential for sperm production and male fertility.

Links

PubMed PMC2951216 Online version:10.1074/jbc.M110.116418

Keywords

Animals; Fertility/physiology; Gene Expression Regulation/physiology; Haploidy; Histone Deacetylases/genetics; Histone Deacetylases/metabolism; Male; Mice; Mice, Knockout; Repressor Proteins/genetics; Repressor Proteins/metabolism; Spermatogenesis/physiology; Spermatozoa/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ZMY15

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000018)

Seeded From UniProt

complete

MOUSE:ZMY15

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000018)

Seeded From UniProt

complete

MOUSE:ZMY15

acts_upstream_of_or_within

GO:0007286: spermatid development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3720171

P

  • occurs_in:(CL:0000018)

Seeded From UniProt

complete

MOUSE:ZMY15

enables

GO:0042826: histone deacetylase binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:ZMY15

acts_upstream_of_or_within

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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