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PMID:20657840

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Citation

Thoren, LA, Nørgaard, GA, Weischenfeldt, J, Waage, J, Jakobsen, JS, Damgaard, I, Bergström, FC, Blom, AM, Borup, R, Bisgaard, HC and Porse, BT (2010) UPF2 is a critical regulator of liver development, function and regeneration. PLoS ONE 5:e11650

Abstract

Nonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise from different processes, including erroneous processing and expression of pseudogenes, but also from more regulated events such as alternative splicing coupled NMD (AS-NMD). Thus, the NMD pathway serves both as a silencer of genomic noise and a regulator of gene expression. Given the early embryonic lethality in NMD deficient mice, uncovering the full regulatory potential of the NMD pathway in mammals will require the functional assessment of NMD in different tissues.

Links

PubMed PMC2906512 Online version:10.1371/journal.pone.0011650

Keywords

Animals; Carrier Proteins/genetics; Carrier Proteins/physiology; Cell Cycle/genetics; Cell Cycle/physiology; Chromatin Immunoprecipitation; Gene Expression Profiling; Immunohistochemistry; Immunoprecipitation; Liver/embryology; Liver/metabolism; Mice; Mice, Knockout; Microscopy, Fluorescence; RNA Stability/genetics; Reverse Transcriptase Polymerase Chain Reaction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:RENT2

acts_upstream_of_or_within

GO:0001889: liver development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3790198

P

Seeded From UniProt

complete

MOUSE:RENT2

acts_upstream_of_or_within

GO:0031100: animal organ regeneration

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3790198

P

Seeded From UniProt

complete


See also

References

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