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PMID:20579883

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Citation

Buechling, T, Bartscherer, K, Ohkawara, B, Chaudhary, V, Spirohn, K, Niehrs, C and Boutros, M (2010) Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr. Biol. 20:1263-8

Abstract

Wnt/Wg signaling pathways are of key importance during development and disease. Canonical and noncanonical Wnt/Frizzled (Fz) pathways share a limited number of signaling components that are part of the membrane proximal signaling complex. In Drosophila, Fz and Dishevelled (Dsh) are the only two components known to be involved in both Wnt/beta-catenin and planar cell polarity (PCP) signaling. PCP signaling is required for the planar polarization of epithelial cells, which occurs, for instance, during hair orientation and gastrulation in vertebrates. Both pathways have been studied intensively in the past years. However, it still remains unresolved whether additional components are required at the receptor complex. Here we identify the Drosophila homolog of the mammalian prorenin receptor (dPRR) as a conserved modulator of canonical Wnt/beta-cat and Fz/PCP signaling. We show that dPRR depletion affects Wg target genes in cultured cells and in vivo. PRR is required for epithelial planar polarity in Drosophila and for convergent extension movements in Xenopus gastrulae. Furthermore, dPRR binds to Fz and Fz2 receptors. In summary, our data suggest that dPRR has an evolutionarily conserved role at the receptor level for activation of canonical and noncanonical Wnt/Fz signaling pathways.

Links

PubMed Online version:10.1016/j.cub.2010.05.028

Keywords

Animals; Cell Polarity/physiology; Cells, Cultured; Drosophila/genetics; Drosophila/physiology; Epithelial Cells/metabolism; Epithelial Cells/physiology; Frizzled Receptors/metabolism; Gastrula; RNA Interference; Receptors, Cell Surface/metabolism; Signal Transduction/genetics; Signal Transduction/physiology; Wing/growth & development; Wing/metabolism; Wnt Proteins/metabolism; Xenopus

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:RENR

involved_in

GO:0001736: establishment of planar polarity

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0001085

P

Seeded From UniProt

complete

DROME:RENR

enables

GO:0005109: frizzled binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:RENR

located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:RENR

involved_in

GO:0035317: imaginal disc-derived wing hair organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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