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PMID:20568247

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Citation

Liu, P and Johnson, RL (2010) Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency. Dev. Dyn. 239:2161-71

Abstract

Studies of Lmx1b have shown that it is required for anterior segment formation during embryonic development and that reduction of Lmx1b may contribute to elevated intraocular pressure in the adult. However, whether Lmx1b is required for formation of anterior segment tissues that are associated with regulation of intraocular pressure has not been addressed due to the perinatal lethality of Lmx1b null allele. Here we use conditional deletion strategies to circumvent perinatal lethality. Our results indicate that Lmx1b is required in neural crest-derived periocular mesenchyme for formation of anterior segment tissues, including trabecular meshwork, a critical regulator of intraocular pressure. Furthermore, we show that Lmx1b is essential to maintain proper functioning of those tissues in the adult. Taken together, our results are the first to link a specific transcription factor to trabecular meshwork formation and the first to demonstrate specific requirements for Lmx1b in maintaining the integrity of adult anterior segment.

Links

PubMed Online version:10.1002/dvdy.22347

Keywords

Animals; Cornea/physiology; Homeodomain Proteins/physiology; Intraocular Pressure; LIM-Homeodomain Proteins; Mesoderm/cytology; Mice; Neural Crest/cytology; Trabecular Meshwork/growth & development; Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:LMX1B

acts_upstream_of_or_within

GO:0002930: trabecular meshwork development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158463,MGI:MGI:2386570,MGI:MGI:3714802

P

Seeded From UniProt

complete

MOUSE:LMX1B

acts_upstream_of_or_within

GO:0043010: camera-type eye development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158463,MGI:MGI:2386570,MGI:MGI:3714802

P

  • results_in_development_of:(EMAPA:36594)

Seeded From UniProt

complete


See also

References

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