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PMID:20519582

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Citation

Nieto, C, Almendinger, J, Gysi, S, Gómez-Orte, E, Kaech, A, Hengartner, MO, Schnabel, R, Moreno, S and Cabello, J (2010) ccz-1 mediates the digestion of apoptotic corpses in C. elegans. J. Cell. Sci. 123:2001-7

Abstract

During development, the processes of cell division, differentiation and apoptosis must be precisely coordinated in order to maintain tissue homeostasis. The nematode C. elegans is a powerful model system in which to study cell death and its control. C. elegans apoptotic cells condense and form refractile corpses under differential interference contrast (DIC) microscopy. Activation of the GTPase CED-10 (Rac) in a neighbouring cell mediates the recognition and engulfment of the cell corpse. After inclusion of the engulfed corpse in a phagosome, different proteins are sequentially recruited onto this organelle to promote its acidification and fusion with lysosomes, leading to the enzymatic degradation of the cell corpse. We show that CCZ-1, a protein conserved from yeasts to humans, mediates the digestion of these apoptotic corpses. CCZ-1 seems to act in lysosome biogenesis and phagosome maturation by recruiting the GTPase RAB-7 over the phagosome.

Links

PubMed Online version:10.1242/jcs.062331

Keywords

Animals; Apoptosis; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Lysosomes/genetics; Lysosomes/metabolism; Phagosomes/genetics; Phagosomes/metabolism; Protein Transport; Vesicular Transport Proteins/genetics; Vesicular Transport Proteins/metabolism; rac GTP-Binding Proteins/genetics; rac GTP-Binding Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:Q9XVL8

involved_in

GO:0016192: vesicle-mediated transport

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00296459
WB:WBVar00296460
WB:WBVar00296461

P

Seeded From UniProt

complete

CAEEL:Q9XVL8

located_in

GO:0045335: phagocytic vesicle

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:Q9XVL8

involved_in

GO:0007040: lysosome organization

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00296460

P

Seeded From UniProt

complete

CAEEL:Q9XVL8

involved_in

GO:0090387: phagolysosome assembly involved in apoptotic cell clearance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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