PMID:20415737

Citation	Latonen, L, Järvinen, PM, Suomela, S, Moore, HM, Saarialho-Kere, U and Laiho, M (2010) Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. Photodermatol Photoimmunol Photomed 26:70-7
Abstract	Cysteine-rich protein 1 (CRP1) is a growth-inhibitory cytoskeletal protein that is induced by ultraviolet (UV) C radiation radiation in fibroblasts. Our aim was to investigate the effects of UV radiation on CRP1 in keratinocytes, the main cell type subjected to UV radiation in the human body.
Links	PubMed Online version:10.1111/j.1600-0781.2010.00488.x
Keywords	Adolescent; Adult; Aged; Aged, 80 and over; Apoptosis/radiation effects; Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/pathology; Caspases/metabolism; Cell Line, Tumor; Dose-Response Relationship, Radiation; Female; Humans; Keratinocytes/metabolism; Keratinocytes/pathology; Keratosis, Actinic/metabolism; Keratosis, Actinic/pathology; Male; Middle Aged; Nuclear Proteins/biosynthesis; Skin/metabolism; Skin/pathology; Skin Neoplasms/metabolism; Skin Neoplasms/pathology; Ultraviolet Rays/adverse effects
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:CRIP1	located_in	GO:0005737: cytoplasm	ECO:0000314: direct assay evidence used in manual assertion		C	part_of:(CL:0000312) exists_during:(GO:0006955)	Seeded From UniProt	complete
HUMAN:CRIP1	involved_in	GO:0006955: immune response	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:CRIP1	involved_in	GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage	ECO:0000314: direct assay evidence used in manual assertion		P	happens_during:(GO:0071493)	Seeded From UniProt	complete
HUMAN:CRIP1	involved_in	GO:0071236: cellular response to antibiotic	ECO:0000314: direct assay evidence used in manual assertion		P	has_input:(CHEBI:15738) occurs_in:(CL:0000312)	Seeded From UniProt	complete
HUMAN:CRIP1	involved_in	GO:0071493: cellular response to UV-B	ECO:0000314: direct assay evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
MOUSE:CRIP1	located_in	GO:0005737: cytoplasm	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	C		Seeded From UniProt	complete
MOUSE:CRIP1	involved_in	GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	P		Seeded From UniProt	complete
MOUSE:CRIP1	involved_in	GO:0071236: cellular response to antibiotic	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	P		Seeded From UniProt	complete
MOUSE:CRIP1	involved_in	GO:0071493: cellular response to UV-B	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	P		Seeded From UniProt	complete
RAT:CRIP1	located_in	GO:0005737: cytoplasm	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	C		Seeded From UniProt	complete
RAT:CRIP1	involved_in	GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	P		Seeded From UniProt	complete
RAT:CRIP1	involved_in	GO:0071236: cellular response to antibiotic	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	P		Seeded From UniProt	complete
RAT:CRIP1	involved_in	GO:0071493: cellular response to UV-B	ECO:0000250: sequence similarity evidence used in manual assertion	UniProtKB:P50238	P		Seeded From UniProt	complete

References

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