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PMID:20415737

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Citation

Latonen, L, Järvinen, PM, Suomela, S, Moore, HM, Saarialho-Kere, U and Laiho, M (2010) Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. Photodermatol Photoimmunol Photomed 26:70-7

Abstract

Cysteine-rich protein 1 (CRP1) is a growth-inhibitory cytoskeletal protein that is induced by ultraviolet (UV) C radiation radiation in fibroblasts. Our aim was to investigate the effects of UV radiation on CRP1 in keratinocytes, the main cell type subjected to UV radiation in the human body.

Links

PubMed Online version:10.1111/j.1600-0781.2010.00488.x

Keywords

Adolescent; Adult; Aged; Aged, 80 and over; Apoptosis/radiation effects; Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/pathology; Caspases/metabolism; Cell Line, Tumor; Dose-Response Relationship, Radiation; Female; Humans; Keratinocytes/metabolism; Keratinocytes/pathology; Keratosis, Actinic/metabolism; Keratosis, Actinic/pathology; Male; Middle Aged; Nuclear Proteins/biosynthesis; Skin/metabolism; Skin/pathology; Skin Neoplasms/metabolism; Skin Neoplasms/pathology; Ultraviolet Rays/adverse effects

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CRIP1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:CRIP1

involved_in

GO:0006955: immune response

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CRIP1

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CRIP1

involved_in

GO:0071236: cellular response to antibiotic

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(CHEBI:15738)
  • occurs_in:(CL:0000312)

Seeded From UniProt

complete

HUMAN:CRIP1

involved_in

GO:0071493: cellular response to UV-B

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000312)

Seeded From UniProt

complete

MOUSE:CRIP1

located_in

GO:0005737: cytoplasm

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

C

Seeded From UniProt

complete

MOUSE:CRIP1

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

P

Seeded From UniProt

complete

MOUSE:CRIP1

involved_in

GO:0071236: cellular response to antibiotic

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

P

Seeded From UniProt

complete

MOUSE:CRIP1

involved_in

GO:0071493: cellular response to UV-B

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

P

Seeded From UniProt

complete

RAT:CRIP1

located_in

GO:0005737: cytoplasm

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

C

Seeded From UniProt

complete

RAT:CRIP1

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

P

Seeded From UniProt

complete

RAT:CRIP1

involved_in

GO:0071236: cellular response to antibiotic

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

P

Seeded From UniProt

complete

RAT:CRIP1

involved_in

GO:0071493: cellular response to UV-B

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P50238

P

Seeded From UniProt

complete


See also

References

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