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PMID:20382126
| Citation |
Ye, D, Meurs, I, Ohigashi, M, Calpe-Berdiel, L, Habets, KL, Zhao, Y, Kubo, Y, Yamaguchi, A, Van Berkel, TJ, Nishi, T and Van Eck, M (2010) Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem. Biophys. Res. Commun. 395:387-94 |
|---|---|
| Abstract |
To determine the role of macrophage ATP-binding cassette transporter A5 (ABCA5) in cellular cholesterol homeostasis and atherosclerotic lesion development. |
| Links |
PubMed Online version:10.1016/j.bbrc.2010.04.027 |
| Keywords |
ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Animals; Atherosclerosis/metabolism; Cholesterol/genetics; Cholesterol/metabolism; Female; Lipids/blood; Macrophages/metabolism; Male; Mice; Mice, Knockout; Receptors, LDL/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
MOUSE:ABCA5 |
involved_in |
GO:0043691: reverse cholesterol transport |
ECO:0000305: curator inference used in manual assertion |
GO:0034375 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:ABCA5 |
involved_in |
GO:0033344: cholesterol efflux |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:ABCA5 |
involved_in |
GO:0010745: negative regulation of macrophage derived foam cell differentiation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:ABCA5 |
involved_in |
GO:0034375: high-density lipoprotein particle remodeling |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
HUMAN:ABCA5 |
involved_in |
GO:0043691: reverse cholesterol transport |
ECO:0000305: curator inference used in manual assertion |
GO:0034375 |
P |
Seeded From UniProt |
complete | |
|
HUMAN:ABCA5 |
involved_in |
GO:0033344: cholesterol efflux |
ECO:0000250: sequence similarity evidence used in manual assertion |
UniProtKB:Q8K448 |
P |
Seeded From UniProt |
complete | |
|
HUMAN:ABCA5 |
involved_in |
GO:0010745: negative regulation of macrophage derived foam cell differentiation |
ECO:0000250: sequence similarity evidence used in manual assertion |
UniProtKB:Q8K448 |
P |
Seeded From UniProt |
complete | |
|
HUMAN:ABCA5 |
involved_in |
GO:0034375: high-density lipoprotein particle remodeling |
ECO:0000250: sequence similarity evidence used in manual assertion |
UniProtKB:Q8K448 |
P |
Seeded From UniProt |
complete | |
See also
References
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