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PMID:20382126

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Citation

Ye, D, Meurs, I, Ohigashi, M, Calpe-Berdiel, L, Habets, KL, Zhao, Y, Kubo, Y, Yamaguchi, A, Van Berkel, TJ, Nishi, T and Van Eck, M (2010) Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem. Biophys. Res. Commun. 395:387-94

Abstract

To determine the role of macrophage ATP-binding cassette transporter A5 (ABCA5) in cellular cholesterol homeostasis and atherosclerotic lesion development.

Links

PubMed Online version:10.1016/j.bbrc.2010.04.027

Keywords

ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Animals; Atherosclerosis/metabolism; Cholesterol/genetics; Cholesterol/metabolism; Female; Lipids/blood; Macrophages/metabolism; Male; Mice; Mice, Knockout; Receptors, LDL/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ABCA5

involved_in

GO:0043691: reverse cholesterol transport

ECO:0000305: curator inference used in manual assertion

GO:0034375

P

Seeded From UniProt

complete

MOUSE:ABCA5

involved_in

GO:0033344: cholesterol efflux

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ABCA5

involved_in

GO:0010745: negative regulation of macrophage derived foam cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ABCA5

involved_in

GO:0034375: high-density lipoprotein particle remodeling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ABCA5

involved_in

GO:0043691: reverse cholesterol transport

ECO:0000305: curator inference used in manual assertion

GO:0034375

P

Seeded From UniProt

complete

HUMAN:ABCA5

involved_in

GO:0033344: cholesterol efflux

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q8K448

P

Seeded From UniProt

complete

HUMAN:ABCA5

involved_in

GO:0010745: negative regulation of macrophage derived foam cell differentiation

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q8K448

P

Seeded From UniProt

complete

HUMAN:ABCA5

involved_in

GO:0034375: high-density lipoprotein particle remodeling

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q8K448

P

Seeded From UniProt

complete


See also

References

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Internal error - GONUTS

GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

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Internal error

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[d7124234d18c8cf84769da98] /wiki/index.php/PMID:20382126 Error from line 252 of /usr/local/github/wiki-extensions/wiki-extensions-hulab/AnnotationLinks/AnnotationLinks.php: Call to a member function getIdentifier() on null

Backtrace:

#0 /usr/local/github/wiki-extensions/wiki-extensions-hulab/AnnotationLinks/AnnotationLinks.php(70): AnnotationLinks::getQuickGOannotations(string, array)
#1 /var/www/html/go/wiki/includes/parser/Parser.php(3888): AnnotationLinks::renderAnnotations(NULL, array, Parser, PPFrame_DOM)
#2 /var/www/html/go/wiki/includes/parser/Preprocessor_DOM.php(1362): Parser->extensionSubstitution(array, PPFrame_DOM)
#3 /var/www/html/go/wiki/includes/parser/Parser.php(2942): PPFrame_DOM->expand(DOMElement, integer)
#4 /var/www/html/go/wiki/includes/parser/Parser.php(1293): Parser->replaceVariables(string)
#5 /var/www/html/go/wiki/includes/parser/Parser.php(443): Parser->internalParse(string)
#6 /var/www/html/go/wiki/includes/content/WikitextContent.php(323): Parser->parse(string, Title, ParserOptions, boolean, boolean, integer)
#7 /var/www/html/go/wiki/includes/content/AbstractContent.php(516): WikitextContent->fillParserOutput(Title, integer, ParserOptions, boolean, ParserOutput)
#8 /var/www/html/go/wiki/includes/jobqueue/jobs/RefreshLinksJob.php(231): AbstractContent->getParserOutput(Title, integer, ParserOptions, boolean)
#9 /var/www/html/go/wiki/includes/jobqueue/jobs/RefreshLinksJob.php(126): RefreshLinksJob->runForTitle(Title)
#10 /var/www/html/go/wiki/includes/jobqueue/JobRunner.php(296): RefreshLinksJob->run()
#11 /var/www/html/go/wiki/includes/jobqueue/JobRunner.php(193): JobRunner->executeJob(RefreshLinksJob, Wikimedia\Rdbms\LBFactorySimple, BufferingStatsdDataFactory, integer)
#12 /var/www/html/go/wiki/includes/MediaWiki.php(1002): JobRunner->run(array)
#13 /var/www/html/go/wiki/includes/MediaWiki.php(988): MediaWiki->triggerSyncJobs(integer, MediaWiki\Logger\LegacyLogger)
#14 /var/www/html/go/wiki/includes/MediaWiki.php(912): MediaWiki->triggerJobs()
#15 /var/www/html/go/wiki/includes/MediaWiki.php(727): MediaWiki->restInPeace(string, boolean)
#16 /var/www/html/go/wiki/includes/MediaWiki.php(750): MediaWiki->{closure}()
#17 /var/www/html/go/wiki/includes/MediaWiki.php(557): MediaWiki->doPostOutputShutdown(string)
#18 /var/www/html/go/wiki/index.php(42): MediaWiki->run()
#19 {main}

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