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PMID:20302514
| Citation |
Saini, N and Schaffner, W (2010) Zinc supplement greatly improves the condition of parkin mutant Drosophila. Biol. Chem. 391:513-8 |
|---|---|
| Abstract |
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which oxidative stress is implicated as a major causative factor. Mutations in the gene encoding Parkin, a ubiquitin ligase, are responsible for a familial form of PD. In a Drosophila disease model lacking Parkin (park(25) null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators. Unlike copper and iron, zinc is not redox-active and under most conditions serves as an antioxidant. We find that the condition of parkin mutants raised on zinc-supplemented food is greatly improved. At zinc concentrations where controls begin to show adverse effects as a result of the metal supplement, parkin mutants perform best, as manifested in a higher frequency of reaching adulthood, extended lifespan and improved motoric abilities. |
| Links |
PubMed Online version:10.1515/BC.2010.052 |
| Keywords |
Animals; Antioxidants/pharmacology; Behavior, Animal; DNA-Binding Proteins/genetics; Drosophila; Drosophila Proteins/genetics; Feeding Behavior; Female; Longevity/drug effects; Longevity/genetics; Male; Mutation; Parkinson Disease/genetics; Transcription Factors/genetics; Ubiquitin-Protein Ligases/genetics; Zinc/pharmacology |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0055069: zinc ion homeostasis |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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