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PMID:20203623

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Citation

Glyvuk, N, Tsytsyura, Y, Geumann, C, D'Hooge, R, Hüve, J, Kratzke, M, Baltes, J, Boening, D, Böning, D, Klingauf, J and Schu, P (2010) AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J. 29:1318-30

Abstract

Synaptic vesicle recycling involves AP-2/clathrin-mediated endocytosis, but it is not known whether the endosomal pathway is also required. Mice deficient in the tissue-specific AP-1-sigma1B complex have impaired synaptic vesicle recycling in hippocampal synapses. The ubiquitously expressed AP-1-sigma1A complex mediates protein sorting between the trans-Golgi network and early endosomes. Vertebrates express three sigma1 subunit isoforms: A, B and C. The expressions of sigma1A and sigma1B are highest in the brain. Synaptic vesicle reformation in cultured neurons from sigma1B-deficient mice is reduced upon stimulation, and large endosomal intermediates accumulate. The sigma1B-deficient mice have reduced motor coordination and severely impaired long-term spatial memory. These data reveal a molecular mechanism for a severe human X-chromosome-linked mental retardation.

Links

PubMed PMC2868567 Online version:10.1038/emboj.2010.15

Keywords

Adaptor Protein Complex 1/analysis; Adaptor Protein Complex 1/genetics; Adaptor Protein Complex 1/metabolism; Animals; Behavior, Animal; Cells, Cultured; Clathrin/metabolism; Endosomes/metabolism; Female; Gene Expression; Hippocampus/cytology; Humans; Learning; Memory; Mice; Mice, Knockout; Motor Activity; Neurons/metabolism; Protein Isoforms/analysis; Protein Isoforms/genetics; Protein Isoforms/metabolism; Synaptic Vesicles/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:AP1S1

part_of

GO:0043195: terminal bouton

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32845)

Seeded From UniProt

complete

MOUSE:SYPH

part_of

GO:0043195: terminal bouton

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32845)

Seeded From UniProt

complete

RAT:Q8R525

part_of

GO:0098793: presynapse

ECO:0006004: super-resolution microscopy evidence used in manual assertion

C

  • part_of:(UBERON:0002421)

Seeded From UniProt

complete

MOUSE:AP1S2

acts_upstream_of_or_within

GO:0008542: visual learning

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:5620801

P

Seeded From UniProt

complete

MOUSE:AP1S2

acts_upstream_of_or_within

GO:0036465: synaptic vesicle recycling

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:5620801

P

  • occurs_in:(EMAPA:32845)

Seeded From UniProt

complete

MOUSE:AP1S2

acts_upstream_of_or_within

GO:0050885: neuromuscular process controlling balance

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:5620801

P

Seeded From UniProt

complete

MOUSE:AP1S2

involved_in

GO:0016182: synaptic vesicle budding from endosome

ECO:0001225: knockout evidence used in manual assertion

P

  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

MOUSE:AP1S2

involved_in

GO:0016182: synaptic vesicle budding from endosome

ECO:0006003: electron microscopy evidence used in manual assertion

P

  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

MOUSE:AP1S2

involved_in

GO:0016182: synaptic vesicle budding from endosome

ECO:0006039: genetically encoded fluorescent electrophysiology assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

MOUSE:SYPH

part_of

GO:0043195: terminal bouton

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:32845)

Seeded From UniProt

complete

Notes

See also

References

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