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PMID:20152186

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Citation

Wang, Q, Uhlirova, M and Bohmann, D (2010) Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis. Dev. Cell 18:157-64

Abstract

FGF signaling is a central regulator of branching morphogenesis processes, such as angiogenesis or the development of branched organs including lung, kidney, and mammary gland. The formation of the air sac during the development of the Drosophila tracheal system is a powerful genetic model to investigate how FGF signaling patterns such emerging structures. This article describes the characterization of the Drosophila matrix metalloprotease Mmp2 as an extracellular inhibitor of FGF morphogenetic function. Mmp2 expression in the developing air sac is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling. The signaling function for MMPs described here may not be limited to branching morphogenesis processes.

Links

PubMed Online version:10.1016/j.devcel.2009.11.004

Keywords

Animals; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/embryology; Feedback, Physiological/physiology; Fibroblast Growth Factors/genetics; Fibroblast Growth Factors/metabolism; Gene Expression Regulation, Developmental/physiology; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Morphogenesis/physiology; Organogenesis/physiology; Respiratory System/embryology; Respiratory System/enzymology; Signal Transduction/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:ESCA

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:D2MP

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:D2MP

involved_in

GO:0046331: lateral inhibition

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:D2MP

involved_in

GO:0040037: negative regulation of fibroblast growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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