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PMID:20147552

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Citation

Malartre, M, Ayaz, D, Amador, FF and Martín-Bermudo, MD (2010) The guanine exchange factor vav controls axon growth and guidance during Drosophila development. J. Neurosci. 30:2257-67

Abstract

The Vav proteins are guanine exchange factors (GEFs) that trigger the activation of the Rho GTPases in general and the Rac family in particular. While the role of the mammalian vav genes has been extensively studied in the hematopoietic system and the immune response, there is little information regarding the role of vav outside of these systems. Here, we report that the single Drosophila vav homolog is ubiquitously expressed during development, although it is enriched along the embryonic ventral midline and in the larval eye discs and brain. We have analyzed the role that vav plays during development by generating Drosophila null mutant alleles. Our results indicate that vav is required during embryogenesis to prevent longitudinal axons from crossing the midline. Later on, during larval development, vav is required within the axons to regulate photoreceptor axon targeting to the optic lobe. Finally, we demonstrate that adult vav mutant escapers, which exhibit coordination problems, display axon growth defects in the ellipsoid body, a brain area associated with locomotion control. In addition, we show that vav interacts with other GEFs known to act downstream of guidance receptors. Thus, we propose that vav acts in coordination with other GEFs to regulate axon growth and guidance during development by linking guidance signals to the cytoskeleton via the modulation of Rac activity.

Links

PubMed Online version:10.1523/JNEUROSCI.1820-09.2010

Keywords

Animals; Axons/physiology; Body Patterning; Cell Differentiation; Cell Movement; Central Nervous System/embryology; Central Nervous System/growth & development; Central Nervous System/metabolism; Central Nervous System/ultrastructure; Drosophila/embryology; Drosophila/growth & development; Drosophila/ultrastructure; Larva/growth & development; Larva/metabolism; Larva/ultrastructure; Mutation; Neuroglia/cytology; Neuroglia/metabolism; Photoreceptor Cells, Invertebrate/metabolism; Photoreceptor Cells, Invertebrate/ultrastructure; Proto-Oncogene Proteins c-vav/biosynthesis; Proto-Oncogene Proteins c-vav/genetics; Proto-Oncogene Proteins c-vav/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:VAV

involved_in

GO:0007417: central nervous system development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0024277

P

Seeded From UniProt

complete

DROME:VAV

involved_in

GO:0007417: central nervous system development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0001965

P

Seeded From UniProt

complete

DROME:VAV

involved_in

GO:0007411: axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:VAV

involved_in

GO:0007409: axonogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:VAV

involved_in

GO:0072499: photoreceptor cell axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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