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PMID:20079695

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Citation

Hornyik, C, Terzi, LC and Simpson, GG (2010) The spen family protein FPA controls alternative cleavage and polyadenylation of RNA. Dev. Cell 18:203-13

Abstract

The spen family protein FPA is required for flowering time control and has been implicated in RNA silencing. The mechanism by which FPA carries out these functions is unknown. We report the identification of an activity for FPA in controlling mRNA 3' end formation. We show that FPA functions redundantly with FCA, another RNA binding protein that controls flowering and RNA silencing, to control the expression of alternatively polyadenylated antisense RNAs at the locus encoding the floral repressor FLC. In addition, we show that defective 3' end formation at an upstream RNA polymerase II-dependent gene explains the apparent derepression of the AtSN1 retroelement in fpa mutants. Transcript readthrough accounts for the absence of changes in DNA methylation and siRNA abundance at AtSN1 in fpa mutants, and this may explain other examples of epigenetic transitions not associated with chromatin modification.

Links

PubMed Online version:10.1016/j.devcel.2009.12.009

Keywords

Arabidopsis/genetics; Arabidopsis/growth & development; Arabidopsis/metabolism; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Base Sequence; Epigenesis, Genetic; Flowers/growth & development; Flowers/metabolism; Gene Expression Regulation, Plant; Genes, Plant; Mutation; Plants, Genetically Modified; Polyadenylation; RNA Precursors/genetics; RNA Precursors/metabolism; RNA, Antisense/genetics; RNA, Antisense/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Plant/genetics; RNA, Plant/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Retroelements

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:FPA

involved_in

GO:0006378: mRNA polyadenylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:FPA

colocalizes_with

GO:0000785: chromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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