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PMID:20079641

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Citation

Arboleda-Estudillo, Y, Krieg, M, Stühmer, J, Licata, NA, Muller, DJ and Heisenberg, CP (2010) Movement directionality in collective migration of germ layer progenitors. Curr. Biol. 20:161-9

Abstract

Collective cell migration, the simultaneous movement of multiple cells that are connected by cell-cell adhesion, is ubiquitous in development, tissue repair, and tumor metastasis [1, 2]. It has been hypothesized that the directionality of cell movement during collective migration emerges as a collective property [3, 4]. Here we determine how movement directionality is established in collective mesendoderm migration during zebrafish gastrulation. By interfering with two key features of collective migration, (1) having neighboring cells and (2) adhering to them, we show that individual mesendoderm cells are capable of normal directed migration when moving as single cells but require cell-cell adhesion to participate in coordinated and directed migration when moving as part of a group. We conclude that movement directionality is not a de novo collective property of mesendoderm cells but rather a property of single mesendoderm cells that requires cell-cell adhesion during collective migration.

Links

PubMed Online version:10.1016/j.cub.2009.11.036

Keywords

Animals; Base Sequence; Cell Adhesion; Cell Movement; DNA Primers; Germ Cells/cytology; Microscopy, Confocal; Zebrafish

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A0R4IFF8

involved_in

GO:0003370: cell-cell adhesion involved in mesendodermal cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IFF8

involved_in

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IJR6

involved_in

GO:0003370: cell-cell adhesion involved in mesendodermal cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IJR6

involved_in

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IL00

involved_in

GO:0003370: cell-cell adhesion involved in mesendodermal cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IL00

involved_in

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IQ86

involved_in

GO:0003370: cell-cell adhesion involved in mesendodermal cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:A0A0R4IQ86

involved_in

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:Q90Z37

involved_in

GO:0003370: cell-cell adhesion involved in mesendodermal cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete

DANRE:Q90Z37

involved_in

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-050421-1

P

Seeded From UniProt

complete


See also

References

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