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PMID:20071673

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Citation

Craig, SE, Thummel, R, Ahmed, H, Vasta, GR, Hyde, DR and Hitchcock, PF (2010) The zebrafish galectin Drgal1-l2 is expressed by proliferating Müller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors. Invest. Ophthalmol. Vis. Sci. 51:3244-52

Abstract

The purpose of this study was to identify secreted proteins in the retina of the adult zebrafish that are induced by the selective death of photoreceptors and to test experimentally the function of these proteins during the regeneration of photoreceptors.

Links

PubMed PMC2891476 Online version:10.1167/iovs.09-4879

Keywords

Animals; Cell Count; Cell Death; Cell Proliferation; Electroporation; Galectins/genetics; Galectins/metabolism; Immunoblotting; In Situ Hybridization; Light; Microglia/metabolism; Microglia/pathology; Morpholines/pharmacology; Photoreceptor Cells, Vertebrate/pathology; Photoreceptor Cells, Vertebrate/radiation effects; RNA, Messenger/metabolism; Radiation Injuries, Experimental/metabolism; Radiation Injuries, Experimental/pathology; Regeneration/physiology; Retinal Rod Photoreceptor Cells/physiology; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells/metabolism; Zebrafish; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:Q6IQI2

involved_in

GO:0050769: positive regulation of neurogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101117-6

P

Seeded From UniProt

complete

DANRE:Q6IQI2

involved_in

GO:0090303: positive regulation of wound healing

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101117-6

P

Seeded From UniProt

complete

DANRE:Q6TGN5

involved_in

GO:0050769: positive regulation of neurogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101117-6

P

Seeded From UniProt

complete

DANRE:Q6TGN5

involved_in

GO:0090303: positive regulation of wound healing

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-101117-6

P

Seeded From UniProt

complete


See also

References

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