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PMID:20036747

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Citation

Sun, Y, Liu, Z and Zhang, S (2010) Tissue distribution, developmental expression and up-regulation of p8 transcripts on stress in zebrafish. Fish Shellfish Immunol. 28:549-54

Abstract

The p8 is a transcription factor with a basic helix-loop-helix motif and a nuclear localization signal. A zebrafish p8 cDNA, which consists of 732 bp and encodes 75 amino acids, was identified in this paper. Sequence alignment showed that the bHLH region of p8 was well-conserved during the evolution. Phylogenetic analysis revealed that zebrafish p8 was close to its homologous protein in frog, together clustering to the clade of vertebrates. The zebrafish p8 mRNA expression levels varied much among the detected adult tissues, with the obvious higher expression in backbone and liver. During embryogenesis, the expression of zebrafish p8 mRNA was in higher levels in cleavage stage, decreased from blastula to segmentation stage, but sharply elevated at hatching stage. Quantitative real-time PCR assay suggested up-regulation expressions of zebrafish p8 on a wide range of cellular stressors such as starvation, temperature, osmotic pressure and pH value, implying an important role of p8 gene in response to stress.

Links

PubMed Online version:10.1016/j.fsi.2009.12.010

Keywords

Amino Acid Sequence; Animals; Gene Expression Regulation, Developmental; Hydrogen-Ion Concentration; Molecular Sequence Data; Osmotic Pressure; Peptides/chemistry; Peptides/metabolism; Phylogeny; Sequence Alignment; Stress, Physiological; Temperature; Up-Regulation; Zebrafish/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A2R8Q606

involved_in

GO:0009267: cellular response to starvation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A0A2R8Q606

involved_in

GO:0071502: cellular response to temperature stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A0A2R8Q606

involved_in

GO:0071470: cellular response to osmotic stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:A0A2R8Q606

involved_in

GO:0071467: cellular response to pH

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:E9QCY4

involved_in

GO:0009267: cellular response to starvation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:E9QCY4

involved_in

GO:0071502: cellular response to temperature stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:E9QCY4

involved_in

GO:0071470: cellular response to osmotic stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:E9QCY4

involved_in

GO:0071467: cellular response to pH

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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