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PMID:20023157

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Citation

Minakhina, S and Steward, R (2010) Hematopoietic stem cells in Drosophila. Development 137:27-31

Abstract

The Drosophila lymph gland, the source of adult hemocytes, is established by mid-embryogenesis. During larval stages, a pool of pluripotent hemocyte precursors differentiate into hemocytes that are released into circulation upon metamorphosis or in response to immune challenge. This process is controlled by the posterior signaling center (PSC), which is reminiscent of the vertebrate hematopoietic stem cell niche. Using lineage analysis, we identified bona fide hematopoietic stem cells (HSCs) in the lymph glands of embryos and young larvae, which give rise to a hematopoietic lineage. These lymph glands also contain pluripotent precursor cells that undergo a limited number of mitotic divisions and differentiate. We further find that the conserved factor Zfrp8/PDCD2 is essential for the maintenance of the HSCs, but dispensable for their daughter cells, the pluripotent precursors. Zfrp8/PDCD2 is likely to have similar functions in hematopoietic stem cell maintenance in vertebrates.

Links

PubMed PMC2796932 Online version:10.1242/dev.043943

Keywords

Animals; Apoptosis Regulatory Proteins/genetics; Apoptosis Regulatory Proteins/physiology; Cell Differentiation/genetics; Cell Differentiation/physiology; Drosophila/cytology; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; Hemocytes/cytology; Hemocytes/metabolism; Immunohistochemistry; Lymph Nodes/cytology; Lymph Nodes/metabolism; Pluripotent Stem Cells/cytology; Pluripotent Stem Cells/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q8MZ50

involved_in

GO:0035162: embryonic hemopoiesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MZ50

involved_in

GO:0048103: somatic stem cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W1A3

involved_in

GO:0035162: embryonic hemopoiesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W1A3

involved_in

GO:0048103: somatic stem cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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