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PMID:20007935

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Citation

Pettersson, AT, Laurencikiene, J, Mejhert, N, Näslund, E, Bouloumié, A, Dahlman, I, Arner, P and Rydén, M (2010) A possible inflammatory role of twist1 in human white adipocytes. Diabetes 59:564-71

Abstract

Twist1 is a transcription factor that is highly expressed in murine brown and white adipose tissue (WAT) and negatively regulates fatty acid oxidation in mice. The role of twist1 in WAT is not known and was therefore examined.

Links

PubMed PMC2828644 Online version:10.2337/db09-0997

Keywords

3T3-L1 Cells; Adipocytes, White/cytology; Adipocytes, White/immunology; Adipocytes, White/metabolism; Adiponectin/metabolism; Adult; Animals; Carbon Radioisotopes/diagnostic use; Chemokine CCL2/genetics; Chemokine CCL2/metabolism; Down-Regulation/immunology; Female; Gene Expression/immunology; Genes, Reporter; Humans; Interleukin-6/genetics; Interleukin-6/metabolism; Lipolysis/immunology; Male; Mice; Middle Aged; Nuclear Proteins/genetics; Nuclear Proteins/immunology; Nuclear Proteins/metabolism; Oxidation-Reduction; Palmitates/pharmacology; Promoter Regions, Genetic/physiology; RNA, Small Interfering; Tumor Necrosis Factor-alpha/genetics; Twist Transcription Factor/genetics; Twist Transcription Factor/immunology; Twist Transcription Factor/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:TWST1

involved_in

GO:0032755: positive regulation of interleukin-6 production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TWST1

involved_in

GO:0032000: positive regulation of fatty acid beta-oxidation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TWST1

involved_in

GO:0032760: positive regulation of tumor necrosis factor production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TWST1

involved_in

GO:0071639: positive regulation of monocyte chemotactic protein-1 production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TWST1

involved_in

GO:2000778: positive regulation of interleukin-6 secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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