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PMID:19945405

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Citation

Sieber, MH and Thummel, CS (2009) The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Cell Metab. 10:481-90

Abstract

Triacylglycerol (TAG) homeostasis is an integral part of normal physiology and essential for proper energy metabolism. Here we show that the single Drosophila ortholog of the PXR and CAR nuclear receptors, DHR96, plays an essential role in TAG homeostasis. DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 overexpression leads to starvation resistance and increased TAG levels. We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis. This study provides insights into the regulation of dietary fat metabolism in Drosophila and demonstrates that the regulation of lipid metabolism is an ancestral function of the PXR/CAR/DHR96 nuclear receptor subfamily.

Links

PubMed PMC2803078 Online version:10.1016/j.cmet.2009.10.010

Keywords

Animals; Drosophila; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Fat Body/metabolism; Homeostasis; Lipase/metabolism; Lipid Metabolism; Male; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Starvation; Triglycerides/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:HR96

involved_in

GO:0070873: regulation of glycogen metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:HR96

involved_in

GO:0070328: triglyceride homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:HR96

involved_in

GO:0042594: response to starvation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VPE9

involved_in

GO:0070328: triglyceride homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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