GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:19915591
| Citation |
Ausin, I, Mockler, TC, Chory, J and Jacobsen, SE (2009) IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana. Nat. Struct. Mol. Biol. 16:1325-7 |
|---|---|
| Abstract |
DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2. IDN1 encodes DMS3, an SMC-related protein, and IDN2 encodes a previously unknown double-stranded RNA-binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and small interfering RNA (siRNA)-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway. |
| Links |
PubMed PMC2842998 Online version:10.1038/nsmb.1690 |
| Keywords |
Arabidopsis/physiology; Arabidopsis Proteins/genetics; Arabidopsis Proteins/physiology; Chromosomal Proteins, Non-Histone/genetics; Chromosomal Proteins, Non-Histone/physiology; DNA Methylation; RNA-Binding Proteins/genetics; RNA-Binding Proteins/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
ARATH:IDN2 |
acts_upstream_of_or_within |
GO:0006306: DNA methylation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
ARATH:DMS3 |
involved_in |
GO:0080188: gene silencing by RNA-directed DNA methylation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
ARATH:DMS3 |
acts_upstream_of_or_within |
GO:0006306: DNA methylation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
See also
References
See Help:References for how to manage references in GONUTS.
