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PMID:19906847

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Citation

Babaoglan, AB, O'Connor-Giles, KM, Mistry, H, Schickedanz, A, Wilson, BA and Skeath, JB (2009) Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions. Development 136:4089-98

Abstract

Asymmetric cell divisions generate sibling cells of distinct fates ('A', 'B') and constitute a fundamental mechanism that creates cell-type diversity in multicellular organisms. Antagonistic interactions between the Notch pathway and the intrinsic cell-fate determinant Numb appear to regulate asymmetric divisions in flies and vertebrates. During these divisions, productive Notch signaling requires sanpodo, which encodes a novel transmembrane protein. Here, we demonstrate that Drosophila sanpodo plays a dual role to regulate Notch signaling during asymmetric divisions - amplifying Notch signaling in the absence of Numb in the 'A' daughter cell and inhibiting Notch signaling in the presence of Numb in the 'B' daughter cell. In so doing, sanpodo ensures the asymmetry in Notch signaling levels necessary for the acquisition of distinct fates by the two daughter cells. These findings answer long-standing questions about the restricted ability of Numb and Sanpodo to inhibit and to promote, respectively, Notch signaling during asymmetric divisions.

Links

PubMed PMC2781049 Online version:10.1242/dev.040386

Keywords

Animals; Cell Differentiation/physiology; Cell Division/physiology; Cell Lineage/physiology; Drosophila/embryology; Drosophila/metabolism; Drosophila Proteins/physiology; Embryo, Nonmammalian/embryology; Embryo, Nonmammalian/metabolism; Gene Expression Regulation, Developmental; Juvenile Hormones/physiology; Microfilament Proteins/physiology; Receptors, Notch/physiology; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:NUMB

involved_in

GO:0045746: negative regulation of Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:NUMB

involved_in

GO:0034613: cellular protein localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMI5

involved_in

GO:0008356: asymmetric cell division

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMI5

involved_in

GO:0045747: positive regulation of Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMI5

involved_in

GO:0045746: negative regulation of Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMI5

involved_in

GO:0045035: sensory organ precursor cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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