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PMID:19855022

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Citation

Kennerdell, JR, Fetter, RD and Bargmann, CI (2009) Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans. Development 136:3801-10

Abstract

Wnt signaling through Frizzled proteins guides posterior cells and axons in C. elegans into different spatial domains. Here we demonstrate an essential role for Wnt signaling through Ror tyrosine kinase homologs in the most prominent anterior neuropil, the nerve ring. A genetic screen uncovered cwn-2, the C. elegans homolog of Wnt5, as a regulator of nerve ring placement. In cwn-2 mutants, all neuronal structures in and around the nerve ring are shifted to an abnormal anterior position. cwn-2 is required at the time of nerve ring formation; it is expressed by cells posterior of the nerve ring, but its precise site of expression is not critical for its function. In nerve ring development, cwn-2 acts primarily through the Wnt receptor CAM-1 (Ror), together with the Frizzled protein MIG-1, with parallel roles for the Frizzled protein CFZ-2. The identification of CAM-1 as a CWN-2 receptor contrasts with CAM-1 action as a non-receptor in other C. elegans Wnt pathways. Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring, linking Wnt signaling to specific cells that organize the anterior nervous system.

Links

PubMed PMC2861721 Online version:10.1242/dev.038109

Keywords

Animals; Axons/metabolism; Caenorhabditis elegans/growth & development; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Neurogenesis; Neurons/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; Signal Transduction; Wnt Proteins/genetics; Wnt Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:WNT2

involved_in

GO:0016055: Wnt signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000289

P

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0033564: anterior/posterior axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00088468
WB:WBVar00088469
WB:WBVar00092168

P

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0009948: anterior/posterior axis specification

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00088468
WB:WBVar00088469
WB:WBVar00092168

P

Seeded From UniProt

complete


See also

References

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