PMID:19855022

Citation	Kennerdell, JR, Fetter, RD and Bargmann, CI (2009) Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans. Development 136:3801-10
Abstract	Wnt signaling through Frizzled proteins guides posterior cells and axons in C. elegans into different spatial domains. Here we demonstrate an essential role for Wnt signaling through Ror tyrosine kinase homologs in the most prominent anterior neuropil, the nerve ring. A genetic screen uncovered cwn-2, the C. elegans homolog of Wnt5, as a regulator of nerve ring placement. In cwn-2 mutants, all neuronal structures in and around the nerve ring are shifted to an abnormal anterior position. cwn-2 is required at the time of nerve ring formation; it is expressed by cells posterior of the nerve ring, but its precise site of expression is not critical for its function. In nerve ring development, cwn-2 acts primarily through the Wnt receptor CAM-1 (Ror), together with the Frizzled protein MIG-1, with parallel roles for the Frizzled protein CFZ-2. The identification of CAM-1 as a CWN-2 receptor contrasts with CAM-1 action as a non-receptor in other C. elegans Wnt pathways. Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring, linking Wnt signaling to specific cells that organize the anterior nervous system.
Links	PubMed PMC2861721 Online version:10.1242/dev.038109
Keywords	Animals; Axons/metabolism; Caenorhabditis elegans/growth & development; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Neurogenesis; Neurons/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; Signal Transduction; Wnt Proteins/genetics; Wnt Proteins/metabolism
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
CAEEL:WNT2	involved_in	GO:0016055: Wnt signaling pathway	ECO:0000316: genetic interaction evidence used in manual assertion	WB:WBGene00000289	P		Seeded From UniProt	complete
CAEEL:WNT2	involved_in	GO:0033564: anterior/posterior axon guidance	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00088468 WB:WBVar00088469 WB:WBVar00092168	P		Seeded From UniProt	complete
CAEEL:WNT2	involved_in	GO:0009948: anterior/posterior axis specification	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00088468 WB:WBVar00088469 WB:WBVar00092168	P		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.