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PMID:19851500
| Citation |
Schroeder, K, Jularic, M, Horsburgh, SM, Hirschhausen, N, Neumann, C, Bertling, A, Schulte, A, Foster, S, Kehrel, BE, Peters, G and Heilmann, C (2009) Molecular characterization of a novel Staphylococcus aureus surface protein (SasC) involved in cell aggregation and biofilm accumulation. PLoS ONE 4:e7567 |
|---|---|
| Abstract |
Staphylococci belong to the most important pathogens causing implant-associated infections. Colonization of the implanted medical devices by the formation of a three-dimensional structure made of bacteria and host material called biofilm is considered the most critical factor in these infections. To form a biofilm, bacteria first attach to the surface of the medical device, and then proliferate and accumulate into multilayered cell clusters. Biofilm accumulation may be mediated by polysaccharide and protein factors. |
| Links |
PubMed PMC2761602 Online version:10.1371/journal.pone.0007567 |
| Keywords |
Amino Acid Sequence; Bacterial Adhesion/genetics; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Base Sequence; Biofilms; Blood Platelets/metabolism; Cloning, Molecular; Humans; Membrane Proteins/genetics; Molecular Sequence Data; Polysaccharides/chemistry; Polystyrenes/chemistry; Sequence Homology, Amino Acid; Staphylococcal Infections/genetics; Staphylococcal Infections/microbiology; Staphylococcus aureus/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016020: membrane |
ECO:0000315: |
C |
Figure 8: When the expression of the sasC gene products were inhibited in a S. aureus strain, biofilm production was reduced in comparison to the S. aureus wild type strain. |
complete | ||||
| GO:1900233: positive regulation of single-species biofilm formation on inanimate substrate |
ECO:0000315: |
P |
Figure 8: When the expression of the sasC gene products were inhibited in an S. aureus strain, biofilm production was reduced in comparison to the S. aureus wild type strain. |
complete | ||||
|
part_of |
GO:0016020: membrane |
ECO:0000315: mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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