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PMID:19797623

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Citation

Kim, K, Sato, K, Shibuya, M, Zeiger, DM, Butcher, RA, Ragains, JR, Clardy, J, Touhara, K and Sengupta, P (2009) Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Science 326:994-8

Abstract

Intraspecific chemical communication is mediated by signals called pheromones. Caenorhabditis elegans secretes a mixture of small molecules (collectively termed dauer pheromone) that regulates entry into the alternate dauer larval stage and also modulates adult behavior via as yet unknown receptors. Here, we identify two heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) that mediate dauer formation in response to a subset of dauer pheromone components. The SRBC-64 and SRBC-66 GPCRs are members of the large Caenorhabditis-specific SRBC subfamily and are expressed in the ASK chemosensory neurons, which are required for pheromone-induced dauer formation. Expression of both, but not each receptor alone, confers pheromone-mediated effects on heterologous cells. Identification of dauer pheromone receptors will allow a better understanding of the signaling cascades that transduce the context-dependent effects of ecologically important chemical signals.

Links

PubMed Online version:10.1126/science.1176331

Keywords

Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/physiology; Calcium/metabolism; Cell Line; Chemoreceptor Cells/metabolism; Cyclic AMP/metabolism; Cyclic GMP/metabolism; GTP-Binding Protein alpha Subunits, Gi-Go/physiology; Gene Expression Regulation, Developmental; Genes, Helminth; Guanylate Cyclase/antagonists & inhibitors; Guanylate Cyclase/metabolism; Hexoses/chemistry; Hexoses/physiology; Humans; Mutation; Pheromones/physiology; Receptors, G-Protein-Coupled; Reproduction; Signal Transduction; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:G5ECV4

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:G5ECV4

involved_in

GO:0007186: G protein-coupled receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:G5ECV4

enables

GO:0004930: G protein-coupled receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

CAEEL:G5ECV4

involved_in

GO:0040024: dauer larval development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:O61938

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:O61938

involved_in

GO:0007186: G protein-coupled receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:O61938

enables

GO:0004930: G protein-coupled receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

CAEEL:O61938

involved_in

GO:0040024: dauer larval development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:GPA3

involved_in

GO:0040024: dauer larval development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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