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PMID:19682396

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Citation

Woo, SM, Kim, J, Han, HW, Chae, JI, Son, MY, Cho, S, Chung, HM, Han, YM and Kang, YK (2009) Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells. BMC Neurosci 10:97

Abstract

Studies have provided important findings about the roles of Notch signaling in neural development. Unfortunately, however, most of these studies have investigated the neural stem cells (NSCs) of mice or other laboratory animals rather than humans, mainly owing to the difficulties associated with obtaining human brain samples. It prompted us to focus on neuroectodermal spheres (NESs) which are derived from human embryonic stem cell (hESC) and densely inhabited by NSCs. We here investigated the role of Notch signaling with the hESC-derived NESs.

Links

PubMed PMC3224699 Online version:10.1186/1471-2202-10-97

Keywords

Blotting, Western; Cell Differentiation/physiology; Cell Lineage/physiology; Cells, Cultured; Embryonic Stem Cells/cytology; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Multipotent Stem Cells/cytology; Neural Plate/cytology; Neurogenesis/physiology; Neurons/metabolism; Neurons/physiology; Receptor, Notch1/metabolism; Reverse Transcriptase Polymerase Chain Reaction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:DLL1

involved_in

GO:0007219: Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DLL1

involved_in

GO:0097150: neuronal stem cell population maintenance

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:JAG1

involved_in

GO:0007219: Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:JAG1

involved_in

GO:2000737: negative regulation of stem cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:JAG1

involved_in

GO:0097150: neuronal stem cell population maintenance

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HES1

involved_in

GO:0007219: Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HES1

involved_in

GO:2000737: negative regulation of stem cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HES1

involved_in

GO:0097150: neuronal stem cell population maintenance

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HES5

involved_in

GO:0007219: Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HES5

involved_in

GO:2000737: negative regulation of stem cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HES5

involved_in

GO:0097150: neuronal stem cell population maintenance

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NOTC1

involved_in

GO:2000737: negative regulation of stem cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NOTC1

involved_in

GO:0007219: Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NOTC1

involved_in

GO:0097150: neuronal stem cell population maintenance

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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